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Annual Reports in Combinatorial Chemistry and Molecular Diversity

  • Couverture cartonnée
  • 184 Nombre de pages
Combinatorial chemistry and molecular diversity approaches to scientific and novel product R& D have exploded in the 1990s. Fo... Lire la suite
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Description

Combinatorial chemistry and molecular diversity approaches to scientific and novel product R& D have exploded in the 1990s. For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. The second volume in this series includes contributions on methods, solid phases, purification, analysis, carbohydrates, patent strategies and tactics, diversity profiling and combinatorial series design, and finishes with a survey of chemical libraries yielding biologically active agents and a compendium of solid phase chemistry publications. Each contribution is prepared by a recognized expert resulting in a high quality account of the recent advances in the field.

Contenu

Preface. Introduction; M.R. Pavia, W.H. Moos. Solution-phase combinatorial chemistry; D.M. Coe, C. Storer. New developments in solid phase synthesis; I. Sucholeiki. Recent advances in solid phase synthesis; S.E. Hall. Purification of combinatorial libraries; H.N. Weller. Analytical methods for quality control of combinatorial libraries; W.L. Fitch. Accessing Carbohydrate-based combinatorial libraries through solid phase and solution phase approaches; M.J. Sofia. Patent Strategies in molecular diversity; G.D. Green. Patent tactics in molecular diversity: Things that get around, come around; K. Bozicevic. Advances in diversity profiling and combinatorial series design; D.K. Agrafiotis, et al. Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997; R.E. Dolle. Compendium of solid phase chemistry publications; I.W. James. Author Index. Subject Index.

Informations sur le produit

Titre: Annual Reports in Combinatorial Chemistry and Molecular Diversity
Éditeur:
Code EAN: 9789048152278
ISBN: 978-90-481-5227-8
Format: Couverture cartonnée
Editeur: Springer Netherlands
Genre: Chimie
nombre de pages: 184
Poids: 356g
Taille: H254mm x B178mm x T10mm
Année: 2010
Auflage: Softcover reprint of the original 1st ed. 1999.

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