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An Introduction to Toxicogenomics

  • Livre Relié
  • 348 Nombre de pages
With a focus on toxicology, this text introduces the overall concept underlying microarray/oligonucleotide array-based genomic ana... Lire la suite
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Description

With a focus on toxicology, this text introduces the overall concept underlying microarray/oligonucleotide array-based genomic analysis and how it fits into the field of biomedical research. It also includes the basics of data analysis and clustering methods.

Texte du rabat

Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new subdiscipline. With a focus on toxicology, it introduces the overall concept underlying microarray/oligonucleotide array-based genomic analysis and how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. An important feature is the book's focus on the basics of data analysis and clustering methods, such as genetic algorithms, used for analyzing large-scale datasets derived from gene chip expression data.

Contenu

FUNDAMENTALS OF EXPRESSION PROFILING ANALYSIS Preparation and Utilization of Microarrays, Sophie Wildsmith and Fiona Spence Comparative Studies Using cDNA versus Oligonucleotide Arrays, Jiang Li and Jeffrey A. Johnson Quality Control of Expression Profiling Data, Andrew Hill and Maryann Whitley An Introduction to Cluster Analysis, Frederick Immermann and Youping Huang EXPRESSION PROFILING AND TOXICOLOGY: THE ADVENT OF TOXICOGENOMICS Transcriptional Profiling in Toxicology, Julia Scheel, Marie-Charlotte von Brevern, and Thorsten Storck MODEL SYSTEMS IN TOXICOGENOMIC STUDIES Microarrays in Drug Metabolism and Toxicology: Rat Liver Responses to Prototypical CYP Inducers, David Gerhold, Jian Xu, and Thomas Rushmore Characterization of Hepatocytes and Their Use as a Model System in Toxicogenomics, Thomas K. Baker, Marnie A. Higgins, Mark. A. Carfagna, and Timothy P. Ryan MECHANISTIC TOXICOGENOMICS Molecular Signatures of Dioxin Toxicity, J. Kevin Kerzee, Craig R. Tomlinson, Jennifer L. Marlowe, and Alvaro Puga Toxicogenomic Dissection of the Antioxidant Response, Jiang Li and Jeffrey A. Johnson An Overview of Mechanistic Toxicogenomic Studies, Julia Scheel, Marie-Charlotte von Brevern, and Thorsten Storck PREDICTIVE TOXICOGENOMICS Gene Expression Profile Databases in Toxicity Testing, Robert T. Dunn II and Kyle L. Kolaja Predictive Toxicogenomics, Mark W. Porter, Arthur L. Castle, Michael S. Orr, and Donna L. Mendrick Unsupervised Hierarchical Clustering of Toxicants, Jeffrey F. Waring and Roger G. Ulrich Toxicogenomic Analysis in Clinical Phamacogenomic Studies, Michael E. Burczynski THE FUTURE OF TOXICOGENOMICS The Future of Toxicogenomics, John C. Rockett

Détails sur le produit

Titre: An Introduction to Toxicogenomics
Éditeur:
Code EAN: 9780849313349
ISBN: 978-0-8493-1334-9
Format: Livre Relié
Editeur: Taylor & Francis Inc
Genre: Médecine
nombre de pages: 348
Poids: 794g
Taille: H254mm x B178mm
Année: 2003
Auflage: New.