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Vaccine Design

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This text provides a practical guide providing step-by-step protocol to design and develop vaccines. Chapters detail protocols for... Weiterlesen
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This text provides a practical guide providing step-by-step protocol to design and develop vaccines. Chapters detail protocols for developing novel vaccines against infectious bacteria, viruses, fungi, and parasites for humans and animals. Volume 2: Vaccines for Veterinary Diseases includes vaccines for farm animals and fishes, vaccine vectors and production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation and intellectual property. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Vaccine Design: Methods and Protocols, Volume 2: Vaccines for Veterinary Diseases aims to ensure successful results in the further study of this vital field.

Includes cutting-edge methods and protocols

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from the experts


Part I Challenges in Veterinary Vaccine Development

1. Challenges in Veterinary Vaccine Development and Immunization

Mark A. Chambers, Simon P. Graham, and Roberto M. La Ragione

Part II Vaccines for Farm Animals

2. Development of Mycoplasma hyopneumoniae Recombinant Vaccines

Silvana Beutinger Marchioro, Simone Simionatto, and Odir Dellagostin

3. Computational Prediction of Immunodominant Epitopes on Outer Membrane Protein (Omp) H of Pasteurella Multocida towards Designing of a Peptide Vaccine

Bhaskar Ganguly

4. DNA Vaccines against Maedi-Visna Virus

Ana M. Henriques, Miguel Fevereiro, and Gabriel A. Monteiro

5. Detection of Avian Antigen-Specific T cells Induced by Viral Vaccines

Tina Sørensen Dalgaard, Liselotte Rothmann Norup, and Helle Risdahl Juul-Madsen

6. Generation of Newcastle Disease Virus (NDV) Recombinants Expressing the Infectious Laryngotracheitis Virus (ILTV) Glycoprotein gB or gD as Dual Vaccines

Wei Zhao, Stephen Spatz, Laszlo Zsak, and Qingzhong Yu

7. A Reverse Genetics Approach for the Design of Methyltransferase-Defective Live Attenuated Avian Metapneumovirus Vaccines

Yu Zhang, Jing Sun, Yongwei Wei, and Jianrong Li

8. Development of Fasciola Vaccine in an Animal Model

Krai Meemon, and Pras

ert Sobhon

9. Development of Experimental Vaccines against Liver Flukes

Huan Yong Yap and Peter M. Smooker

10. Towards a Preventive Strategy for Toxoplasmosis: Current Trends, Challenges, and Future Perspectives for Vaccine Development

Ragab M. Fereig and Yoshifumi Nishikawa

11. DNA V

accination in Chickens

Shishir Kumar Gupta, Sohini Dey, and Madhan Mohan Chellappa

PART III Vaccines for Fishes and Shellfish

12. Selection of Vaccine Candidates for Fish Pasteurellosis Using a Reverse Vaccinology and an In Vitro Screening Approach

Francesca Andreoni, Giulia Amagliani, and Mauro Magnani

13. Development of Vaccines against Nocardia in Fishes

Sukanta K. Nayak and Teruyuki Nakanishi

14. Design of an Immersion Vaccine against Aeromonad Septicaemia in Perch (Perca fluviatilis L.).

Joachim Frey, Sarah E. Burr, and Thomas Wahli

15. Prokaryotic Production of Virus-Like Particle Vaccine of Betanodavirus

Junfeng Xie, Runqing Huang, and Yuxiong Lai

16. Design an

d Construction of Shrimp Antiviral DNA Vaccines Expressing Long and Short Hairpins for Protection by RNA Interference

Aparna Chaudhari, Gireesh Babu P, and A. Pavan Kumar

PART IV Vaccines against Ticks

17. Developing Anti-Tick Vaccines


ina Rodríguez-Mallon

18. Host Immunization with Recombinant Proteins to Screen Antigens for Tick Control

Remil Linggatong Galay, Takeshi Miyata, Rika Umemiya-Shirafuji,

Masami Mochizuki, Kozo Fujisaki, and Tetsuya Tanaka

19. Vaccinomics Approach to Tick Vaccine Development

Marinela Contreras, Margarita Villar, Pilar Alberdi, and José de la Fuente

Part V Vaccine Adjuvants

20. Development of CpG ODN Based Vaccine Adjuvant Formulations

Mayda Gursel and Ihsan Gursel

Part VI Vaccine Vectors and Producti

on Systems

21. Assembly and Assessment of DNA Scaffolded Vaccines

Xiaowei Liu, Lili Wang, Hao Yan, and Yung Chang

22. Alphavirus-based Vaccines

Kenneth Lundstrom

23. Vaccine Design: Replication-Defective Adenovirus Vectors

Xiangyang Zhou, Zhiquan Xiang, and Hildegund C.J. Ertl

24. Generation of Lymphocytic Choriomeningitis Virus based Vaccine Vectors

Sandra Ring and Lukas Flatz

25. Production of Japanese Encephalitis Virus-like Particles Using Insect Cell Expression Systems

Hideki Yamaji and Eiji Konishi

26. Subunit Protein Vaccine Delivery System for Tuberculosis Based on Hepatitis B Virus Core VLP (HBc-VLP) Particles

Dhananjayan Dhanasooraj, Ajay Kumar R, and Sathish Mundayoor

27. Formulation Studies during Preclinical Development of Influenza Hemagglutinin and Virus-like Particle Vaccine Candidates

Newton Wahome, John M. Hickey, David B. Volkin, and C. Russell Middaugh

28. Strategies for Vaccine Design using Phage Display-Derived Peptides

Luiz R. Gou

lart and Paula de S. Santos

29. Production of Well-Characterized Virus-Like Particles in an Escherichia coli based Expression Platform for Preclinical Vaccine Assessments

Newton Wahome, Anne Cooper, Prem Thapa, Shyamal Choudhari, Fei P. Gao, David B. Volkin, and C. Russell Middaugh

30. Laboratory Scale Production of Recombinant Haa86 Tick Protein in Pichia pastoris and in Escherichia coli System

Binod Kumar, Azhahianambi P, and Ghosh Srikant

31. Production and Purification of Recombinant Filamentous Bacteriophages Displaying Immunogenic Heterologous Epitopes

Lei Deng, Florencia Linero, and Xavier Saelens

32. Oral Vaccine Development by Molecular Display Methods using Microbial Cells

Seiji Shibasaki and Mitsuyoshi Ueda

33. Facile Method for the Production of Recombinant Cholera Toxin B Subunit in E. Coli

Krystal Hamorsky and Nobuyuki Matoba

34. Immunoproteomic Approach for Screening Vaccine Candidates from Bacterial Outer Membrane Proteins

Jianyi Pan, Chuchu Li, and Zhicang Ye

35. Construction and Immunogenicity Testing of Whole Recombinant Yeast-Based T cell Vaccines

Thomas H. King, Zhimin Guo, Melanie Hermreck, Donald Bellgrau, and Timothy C. Rodell

36. Oral Rabies Vaccine Design For Expression in Plants

Ankit Singh, Gauri Saxena, and Praveen C. Verma

37. Purification of Virus-like Particles (VLPs) from Plants

Albertha R. van Zyl, and Inga I. Hitzeroth

38. Transient Expression of Viral Proteins in Plants using Agrobacterium tumefaciens

Inga I. Hitzeroth, and Albertha R. van Zyl

39. A Plant-Based Transient Expression System for the Rapid Production of Malaria Vaccine Candidates

Alexander Boes, Andreas Reimann, Richard M Twyman, Rainer Fischer, Stefan Schillberg, and Holger Spiegel

40. Recombinant Botulinum Toxoids: A Practical Guide for Production

Gustavo Marçal S.G. Moreira, Clóvis Moreira Jr., Carlos Eduardo P. da Cunha, Marcelo Mendonça, and Fabricio R. Conceição

41. Practical Approaches to Forced Degradation Studies of Vaccines

Manvi Hasija, Sepideh Aboutorabian, Nausheen Rahman, and Salvador F Ausar

PART VII Vaccine Delivery Systems

42. Preparation of Multifunctional Liposomes as a Stable Vaccine Delivery-Adjuvant System by Procedure of Emulsification-Lyophilization


g Wang, and Ning Wang

43. Preparation of the Multifunctional Liposome-Containing Microneedle Arrays as an Oral Cavity Mucosal Vaccine Adjuvant-Delivery System

Ting Wang, and Ning Wang

44. Preparation and Characterization of PLGA Encapsulated Protective Antigen Domain 4 Nanoformulation

Manish Manish, Rakesh Bhatnagar, and Samer Singh

45. Attenuated Salmonella sp. as a DNA Delivery Dystem for T. cruzi Antigens

Augusto E. Bivona, Natacha Cerny, Andrés Sánchez Alberti, Silvia I. Cazorla, and Emilio L. Malchiodi

46. Poly-e-Caprolactone/Chitosan and Chitosan Particles: Two Recombinant Antigen Delivery Systems for Intranasal Vaccination

Sandra Jesus, Edna Soares, and Olga Borges

47. Micro-Fractional Epidermal Powder Delivery for Skin Vaccination

Feng Jia, Shengwu Liu, Mei X. Wu, and Xinyuan Chen

Part VIII Vaccine Bioinformatics

48. A Bioinformatics Method for the Design of Live Attenuated Virus Vaccine Utilizing Host microRNA Response Elements

Duangdao Wichadakul

49. The Web-based DNA Vaccine Dat

abase DNAVaxDB and its Usage for Rational DNA Vaccine Design

Rebecca Racz and Yongqun He

50. MetaMHCpan, a Meta Approach for Pan-Specific MHC Peptide Binding Prediction

Yichang Xu, Cheng Luo, Hiroshi Mamits

uka, and Shanfeng Zhu

51. A Cohesive and Integrated Platform for Immunogenicity Prediction

Ivan Dimitrov, Mariyana Atanasova, Atanas Patronov, Darren R. Flower, and

Irini Doytchinova

Part IX Vaccine Safety and Regulation

52. The Regulatory Evaluation of Vaccines for Human Use

Norman W. Baylor

PART X Vaccine Intellectual Property

53. Vaccines and IP Rights: A Multifaceted Relationship

Karen Durell

54. From the Bench to the Pharmacy: Protecting Innovation during Vaccine Development and Commercialization

Adam C. Krol, Muna Abu-Shaar, and Paul Brady

55. Intellect

ual Property in Vaccine Innovation: Impact of Recent Patent Developments

Elizabeth Siew-Kuan Ng


Titel: Vaccine Design
Untertitel: Methods and Protocols, Volume 2: Vaccines for Veterinary Diseases
EAN: 9781493933884
ISBN: 978-1-4939-3388-4
Format: Fester Einband
Herausgeber: Springer, Berlin
Genre: Medizin
Anzahl Seiten: 854
Gewicht: 1828g
Größe: H50mm x B257mm x T187mm
Jahr: 2016
Auflage: 1st ed. 2016

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