Tumor Prevention and Genetics

This book presents a comprehensive update of the latest findings in oncogenetics. It also investigates the relevance of preclinical models with respect to clinical cancer prevention (primary and secondary) for major cancer types such as breast, skin, lung, prostate and colon cancer.

Inhalt
1 Latest News in Cancer Genetics.- Genetic Susceptibility, Predicting Risk and Preventing Cancer.- Novel Approaches to Identify Low Penetrance Cancer Susceptibility Genes Using Mouse Models.- 2 Assessing New Cancer Susceptibility Genes.- Development of Novel Selective Cell Ablation in the Mammary Gland and Brain to Study Cell-Cell Interactions and Chemoprevention.- Mouse Skin as a Model for Cancer Chemoprevention by Nonsteroidal Anti-Inflammatory Drugs Friedrich Marks, Gerhard Fürstenberger; Gitta Neufang,.- Preclinical Models for Chemoprevention of Colon Cancer.- New Cancer Biomarkers Deriving from the NCI Early Detection Research.- 3 Update in Chemoprevention of Breast Cancer.- Tamoxifen's Impact as a Preventive Agent in Clinical Practice and an Update on the STAR Trial.- Aromatase Inhibitors in Prevention Data from the ATAC (Arimidex, Tamoxifen Alone orin Combination) Trial and the Design of IBIS-II (The Second International Breast Cancer Intervention Study).- HRT Opposed by Low Dose Tamoxifen (HOT Study). Rationale and Design.- 4 Secondary Prevention of Breast Cancer: The Mammography Controversy.- Is Mammography Screening for Breast Cancer Really Not Justifiable?.- How Reliable is the Evidence for Screening Mammography?.- Political Interpretation of Scientific Evidence Case Study of Breast Cancer Screening Policies Around the World.- 5 Chemoprevention of Skin and Lung Cancer.- Skin Cancer Chemoprevention: Strategies to Save our Skin.- Chemoprevention of Non-Melanoma Skin Cancer: Experience with a Polyphenol from Green Tea.- Chemoprevention of Lung Cancer: New Directions.- Key Issues in Lung Cancer Chemoprevention Trials of New Agents.- 6 Prevention and Screening of Prostate Cancer.- Prevention of Prostate Cancer.- Clinical Models for TestingChemopreventative Agents in Prostate Cancer and Overview of SELECT: The Selenium and Vitamin ECancer Prevention Trial.- Problems with Prostate Specific Antigen Screening: A Critical Review.- 7 Prevention and Screening of Colorectal Cancer.- Genetic Predisposition as a Basis for Chemoprevention, Surgical and Other Interventions in Colorectal Cancer.- Fecal Occult Blood (FOB) Screening Trial Evidence, Practice and Beyond Gad Rennert.- Is FOB-Screening Really the Answer for Lowering Mortality in Colorectal Cancer?.- Summary and Conclusions.