The Stressed Heart

The Stressed Heart is truly unique in concept and will provide an eXCItmg adventure to the reader no matter what his or her field of expertise and interest. The title, although quite appropriate, does not adequately indicate the range of topics considered or the rational interrelationships among them. Indeed, perhaps the most important point to be learned from the book is that a serious consideration of the response of the heart to mechanical overload, ischemia, or excessive humoral stimuli must include evaluation of each of the topics in the table of contents. The heart responds to stress through alterations in both structure and function. How these changes are brought about is the subject of the initial chapters. These consider first the normal regulation of gene expression in the heart, the rapid response to mechanical overload that leads to both quantitative and qualitative changes in the contractile proteins, and our current understand ing of the signals that might be elicited by stress and alter gene expression. One chapter emphasizes the fact that, regardless of the nature of the stress, the common denominator is a discrepancy between energy requirements and expenditure. The central role of cellular acidosis in initiating the sequence of responses to stress and the possible roles of peptide regulators of transcription and protein regulators of translation are considered in detail.

Inhalt

1. Regulation of gene expression in the normal and overloaded heart.- 2. Cell stress and the initiation of growth.- 3. Subcellular growth of cardiocytes during hypertrophy.- 4. Capillarity and the distribution of capillaries and mitochondria in cardiac growth.- 5. The coronary vasculature during myocardial hypertrophy.- 6. Microcirculation in the stressed heart.- 7. Pathology and pathophysiology of the coronary microcirculation in myocardial ischemia.- 8. The biochemistry of myocardial failure.- 9. Force-interval relationship and activator calcium availability: similarities of sympathetic stimulation and hypertrophy and heart failure.- 10. Right atrial ultrastructure in coronary artery disease: characterization of chronic ischemia.- 11. Connective tissue in the normal and hypertrophied heart.- 12. Myocardial hypertrophy and cardiac failure: a complex interrelationship.- 13. The regression of cardiac hypertrophy: functional, anatomic, and hemodynamic considerations.- 14. Regression of left ventricular hypertrophy: clinical considerations.- 15. The cardiocyte in senescence.- 16. Stress and sudden death.