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The Nuclear Receptor Superfamily

  • Fester Einband
  • 260 Seiten
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This volume aims to describe a complementary range of molecular, cell biological, and in vivo protocols used to investigate the st... Weiterlesen
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Beschreibung

This volume aims to describe a complementary range of molecular, cell biological, and in vivo protocols used to investigate the structurefunction of nuclear receptors, together with experimental approaches that may lead to new drugs to selectively target nuclear receptor-associated diseases. The Nuclear Receptor Superfamily, Second Edition will benefit those starting out in the nuclear receptor research field as well as to more established researchers who wish to apply different methods to a particular receptor or research problem. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, The Nuclear Receptor Superfamily, Second Edition aims to ensure successful results in the further study of this vital field.



Includes cutting-edge methods and protocols

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from the experts



Inhalt
The Nuclear Receptor Superfamily- At Thirty.- Lipid Homeostasis and Ligands for Liver X Receptors: Identification and Characterization.- Use of Differential Scanning Fluorimetry to Identify Nuclear Receptor Ligands.- Drug-Discovery Pipeline for Novel Inhibitors of the Androgen Receptor.- Use of BRET to Study Protein-Protein Interactions in vitro and in vivo.- Studying Steroid Receptor Complexes in the Cellular Environment.- Post-translational Modifications of Steroid Receptors: Phosphorylation.- Mapping protein-DNA Interactions using ChIP-exo and Illumina-based Sequencing.- Methods to Identify Chromatin Bound Protein Complexes: From Genome-Wide to Locus Specific Approaches.- Measuring the Expression of microRNAs Regulated by Androgens.- Methods for Identifying and Quantifying Mrna Expression of Androgen Receptor Splicing Variants in Prostate Cancer.- Harvesting Human Prostate Tissue Material and Culturing Primary Prostate Epithelial Cells.- In vivo Imaging of Nuclear Receptor Transcriptional Activity.- Development and Characterisation of Cell-Specific Androgen Receptor Knockout Mice.

Produktinformationen

Titel: The Nuclear Receptor Superfamily
Untertitel: Methods and Protocols
Editor:
Mcewan
EAN: 9781493937226
ISBN: 1493937227
Format: Fester Einband
Herausgeber: Springer New York
Anzahl Seiten: 260
Gewicht: 693g
Größe: H260mm x B183mm x T20mm
Jahr: 2016
Untertitel: Englisch
Auflage: 2nd ed. 2016

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