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The Gene Ontology Handbook

  • Fester Einband
  • 305 Seiten
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This book is open access under a CC BY 4.0 license. This book provides a practical and self-contained overview of the Gene Ontolog... Weiterlesen
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Beschreibung

This book is open access under a CC BY 4.0 license.

This book provides a practical and self-contained overview of the Gene Ontology (GO), the leading project to organize biological knowledge on genes and their products across genomic resources. Written for biologists and bioinformaticians, it covers the state-of-the-art of how GO annotations are made, how they are evaluated, and what sort of analyses can and cannot be done with the GO. In the spirit of the Methods in Molecular Biology book series, there is an emphasis throughout the chapters on providing practical guidance and troubleshooting advice. Authoritative and accessible, The Gene Ontology Handbook serves non-experts as well as seasoned GO users as a thorough guide to this powerful knowledge system.



Features chapters on the fundamentals of Gene Ontology, its use in gene annotation, and its application in bioinformatic analyses

Emphasizes providing practical guidance and troubleshooting advice

Assumes no prior knowledge yet serves as an informative and useful text for experts as well

Includes supplementary material: sn.pub/extras



Klappentext
This book is open access under a CC BY 4.0 license.

This book provides a practical and self-contained overview of the Gene Ontology (GO), the leading project to organize biological knowledge on genes and their products across genomic resources. Written for biologists and bioinformaticians, it covers the state-of-the-art of how GO annotations are made, how they are evaluated, and what sort of analyses can and cannot be done with the GO. In the spirit of the Methods in Molecular Biology book series, there is an emphasis throughout the chapters on providing practical guidance and troubleshooting advice. 
Authoritative and accessible, The Gene Ontology Handbook serves non-experts as well as seasoned GO users as a thorough guide to this powerful knowledge system.



Inhalt
Part I: Fundamentals 1. Primer on Ontologies Janna Hastings 2. The Gene Ontology and the Meaning of Biological Function Paul D. Thomas 3. Primer on the Gene Ontology Pascale Gaudet, Nives kunca, James C. Hu, and Christophe Dessimoz Part II: Making Gene Ontology Annotations 4. Best Practices in Manual Annotation with the Gene Ontology Sylvain Poux and Pascale Gaudet 5. Computational Methods for Annotation Transfers from Sequence Domenico Cozzetto and David T. Jones 6. Text Mining to Support Gene Ontology Curation and Vice Versa Patrick Ruch 7. How Does the Scientific Community Contribute to Gene Ontology? Ruth C. Lovering Part III: Evaluating Gene Ontology Annotations 8. Evaluating Computational Gene Ontology Annotations Nives kunca, Richard J. Roberts, and Martin Steffen 9. Evaluating Functional Annotations of Enzymes Using the Gene Ontology Gemma L. Holliday, Rebecca Davidson, Eyal Akiva, and Patricia C. Babbitt10. Community-Based Evaluation of Computational Function Prediction Iddo Friedberg and Predrag Radivojac Part IV: Using the Gene Ontology 11. Get GO!: Retrieving GO Data Using AmiGO, QuickGO, API, Files, and Tools Monica Munoz-Torres and Seth Carbon 12. Semantic Similarity in the Gene Ontology Catia Pesquita 13. Gene-Category Analysis Sebastian Bauer 14. Gene Ontology: Pitfalls, Biases, and Remedies Pascale Gaudet and Christophe Dessimoz 15. Visualizing GO Annotations Fran Supek and Nives kunca 16. A Gene Ontology Tutorial in Python Alex Warwick Vesztrocy and Christophe Dessimoz Part V: Advanced Gene Ontology Topics <17. Annotation Extensions Rachael P. Huntley and Ruth C. Lovering 18. The Evidence and Conclusion Ontology (ECO): Supporting GO Annotations Marcus C. Chibucos, Deborah A. Siegele, James C. Hu, and Michelle Giglio Part VI: Beyond the Gene Ontology 19. Complementary Sources of Protein Functional Information: The Far Side of GONicholas Furnham 20. Integrating Bio-Ontologies and Controlled Clinical Terminologies: From Base Pairs to Bedside Phenotypes Spiros C. Denaxas Part VII: Conclusion 21. The Vision and Challenges of the Gene Ontology Suzanna E. Lewis

Produktinformationen

Titel: The Gene Ontology Handbook
Editor:
EAN: 9781493937417
ISBN: 978-1-4939-3741-7
Format: Fester Einband
Herausgeber: Springer, Berlin
Genre: Biologie
Anzahl Seiten: 305
Gewicht: 802g
Größe: H25mm x B259mm x T186mm
Jahr: 2016
Untertitel: Englisch
Auflage: 1st ed. 2017

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