Systems Medicine

This volume guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach. Chapters provide an outlook on the role that systems medicine may or should play in various medical fields, and describe different facets of the systems medicine approach in action. Ultimately it introduces tools, resources and methodologies from bioinformatics and systems biology, and how to apply these in a systems medicine project. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, and discuss experimental and computational approaches, methods, and tools that should be considered for a successful systems medicine project. Systems Medicine aims to motivate and provide guidance for collaborations across disciplines to tackle today's challenges related to human healthand well-being.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts Includes supplementary material: sn.pub/extras

Inhalt

Systems Medicine - Sketching The Landscape.- Taking Bioinformatics to Systems Medicine.- Systems Medicine: The Future of Medical Genomics, Healthcare and Wellness.- Next Generation Pathology.- Training in Systems Approaches for the next Generation of Life Scientists and Medical Doctors.- Systems Medicine in Pharmaceutical Research and Development.- Systems Medicine and Infection.- Systems Medicine for Lung Diseases Phenotypes and Precision Medicine in Cancer, Infection and Allergy.- Third-Kind Encounters In Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive.- Systems Medicine In Oncology: Signaling-Networks Modeling and New Generation Decision-Support Systems.- Neurological Diseases from a Systems Medicine Point of View.- Computational Modeling of Human Metabolism and its Application to Systems Biomedicine.- From Systems Understanding To Personalized Medicine - Lessons and Recommendations Based on a Multi-Disciplinary and Translational Analysis of COPD.- Rna Systems Biology for Cancer: From Diagnosis to Therapy.- Mathematical Models Of Pluripotent Stem Cells: at the Dawn of Predictive Regenerative Medicine.- Network Assisted Disease Classification and Biomarker Discovery.- Anatomy and Physiology of Multiscale Modeling and Simulation in Systems Medicine.- Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway As A Case Study.- Modelling and Simulation Tools: from Systems

Biology to Systems Medicine.