Systems Biology in Drug Discovery and Development

Here is a practical, holistic view of the uses of systems biology to
achieve better drug discovery and personalized medicine. Leading experts describe cutting-edge technologies and show how they apply to understanding of disease and therapeutic discovery.

Due to the failing one-drug-fits-all model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the technologies can be applied in science for disease understanding and therapeutic discovery. As a volume in the highly successful Methods in Molecular Biology™ series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and up-to-date, Systems Biology in Drug Discovery and Development: Methods and Protocols covers topics from fundamental concepts to advanced technologies in order to best serve biomedical students and professionals at all levels who are interested in vital integrative studies in molecular biology, genetics, bioinformatics, bioengineering, biochemistry, physiology, pathology, microbiology, immunology, pharmacology, toxicology, drug discovery, and clinical medicine.

Focuses on translational methods through applying systems biology approaches directly in drug development and clinical practice Aims toward the goal of truly personalized medicine Features expert tips from successful labs from around the world

Inhalt
Methodologies of Systems Biology in Drug Discovery and Development.- Proteomics and Systems Biology: Application in Drug Discovery and Development.- Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-target Drugs.- Systems Biology On-the-Fly: SILAC-Based Quantitative Proteomics and RNAi Approach in Drosophila melanogaster.- Systems Biology of Cell Behavior.- Computational Modeling in Systems Biology.- An Introduction to Gaussian Bayesian Networks.- Derivation of Large-Scale Cellular Regulatory Networks from Biological Time Series Data.- Translational Bioinformatics and Systems Biology Approaches for Personalized Medicine.- Systems Biology Methods for Disease Treatment and Translational Medicine.- Systems Biology and Inflammation.- Immunoinformatics and Systems Biology Methods for Personalized Medicine.- Systems Biology Approaches to the Study of Cardiovascular Drugs.- Cancer Systems Biology.- Systemic Lupus Erythematosus: From Genes to Organ Damage.- Systems Biology of Influenza: Understanding Multidimensional Interactions for Personalized Prevention and Treatment.- Methods in Systems Biology of Experimental Methamphetamine Drug Abuse.- Systems Biology and Theranostic Approach to Drug Discovery and Development to Treat Traumatic Brain Injury.- Erratum to: Cancer Systems Biology.- Erratum to: Cancer Systems Biology.