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Systems Biology in Drug Discovery and Development

  • Kartonierter Einband
  • 352 Seiten
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Here is a practical, holistic view of the uses of systems biology toachieve better drug discovery and personalized medicine. Leadi... Weiterlesen
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Here is a practical, holistic view of the uses of systems biology to
achieve better drug discovery and personalized medicine. Leading experts describe cutting-edge technologies and show how they apply to understanding of disease and therapeutic discovery.

Due to the failing one-drug-fits-all model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the technologies can be applied in science for disease understanding and therapeutic discovery. As a volume in the highly successful Methods in Molecular Biology™ series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and up-to-date, Systems Biology in Drug Discovery and Development: Methods and Protocols covers topics from fundamental concepts to advanced technologies in order to best serve biomedical students and professionals at all levels who are interested in vital integrative studies in molecular biology, genetics, bioinformatics, bioengineering, biochemistry, physiology, pathology, microbiology, immunology, pharmacology, toxicology, drug discovery, and clinical medicine.

Focuses on translational methods through applying systems biology approaches directly in drug development and clinical practice Aims toward the goal of truly personalized medicine Features expert tips from successful labs from around the world

Part I: Methodologies of Systems Biology in Drug Discovery and Development 1. Proteomics and Systems Biology: Application in Drug Discovery and Development Bulbul Chakravarti, Buddhadeb Mallik, and Deb N. Chakravarti 2. Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-Target Drugs André Schrattenholz, Karlfried Groebe, and Vukic Soskic 3. Systems Biology On-the-Fly: SILAC-Based Quantitative Proteomics and RNAi Approach in D. Melanogaster Alessandro Cuomo and Tiziana Bonaldi 4. Systems Biology of Cell Behaviour Najl V. Valeyev, Declan G. Bates, Yoshinori Umezawa, Antonina N. Gizatullina, and Nikolay V. Kotov 5. Computational Modeling in Systems Biology Ravishankar R. Vallabhajosyula and Alpan Raval 6. An Introduction to Gaussian Bayesian Networks Marco Grzegorczyk 7. Derivation of Large-Scale Cellular Regulatory Networks from Biological Time Series Data Benjamin L. de Bivort 8. Translational Bioinformatics and Systems Biology Approaches for Personalized Medicine Qing Yan Part II: Systems Biology Methods for Disease Treatment and Translational Medicine 9. Systems Biology and Inflammation Yoram Vodovotz and Gary An 10. Immunoinformatics and Systems Biology Methods for Personalized Medicine Qing Yan 11. Systems Biology Approaches to the Study of Cardiovascular Drugs Yuri Nikolsky and Robert Kleemann 12. Cancer Systems Biology Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon, and David J. Harrison 13. Systemic Lupus Erythematosus: From Genes to Organ Damage Vasileios C. Kyttaris 14. Systems Biology of Influenza: Understanding Multi-Dimensional Interactions for Personalized Prevention and Treatment Qing Yan 15. Methods in Systems Biology of Experimental Methamphetamine Drug Abuse Firas H. Kobeissy, Shankar Sadasivan, Melinda Buchanan, Zhiqun Zhang, Mark S Gold, and Kevin K.W. Wang 16. Systems Biology and Theranostic Approach to Drug Discovery and Development to Treat Traumatic BrainInjury Zhiqun Zhang, Stephen F. Larner, Firas Kobeissy, Ronald L. Hayes, and Kevin K.W. Wang


Titel: Systems Biology in Drug Discovery and Development
Untertitel: Methods and Protocols
EAN: 9781493957705
ISBN: 1493957708
Format: Kartonierter Einband
Herausgeber: Humana Press
Genre: Medizin
Anzahl Seiten: 352
Gewicht: 663g
Größe: H254mm x B178mm x T18mm
Jahr: 2016
Auflage: Softcover reprint of the original 1st ed. 2010

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