Suppression and Regulation of Immune Responses

This second volume expands upon the previous edition with new research and objectives in immunoregulation and immune tolerance. Chapters cover topics ranging from new molecular and cellular mechanisms of tolerance; generation and characterization of mice regulatory macrophages; recent advances in the treatment of immune-mediated inflammatory disorders; and novel mechanisms and therapeutic perspectives on food allergies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Suppression and Regulation of Immune Responses: Methods and Protocols, Volume II is a great resource for current research and inspiration for new studies in immune tolerance.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt

HLA-G as an Inhibitor of Immune Responses.- New Molecular and Cellular Mechanisms of Tolerance: Tolerogenic Actions of IL-2.- Expansion of Regulatory T Cells In Vitro and In Vivo by IL-33.- Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function.- Characterization and Immunoregulatory Properties of Innate Pro-B-Cell Progenitors.- Generation and Characterization of Mice Regulatory Macrophages.- Generation and Expansion of T Helper 17 Lymphocytes Ex-Vivo.- Autoimmune Diabetes: An Overview of Experimental Models and Novel Therapeutics.- Recent Advances in the Treatment of Immune-Mediated Inflammatory Disorders.- Application of Humanized Mice in Immunological Research.- Humanized Mice as Pre-Clinical Models in Transplantation.- Dextran Sulfate Sodium (DSS)-Induced Acute Colitis in the Rat.- Corneal Immunosuppressive Mechanisms, Anterior Chamber-Associated Immune Deviation (ACAID) and their Role in Allograft Rejection.- Food Allergies: Novel Mechanisms and Therapeutic Perspectives.- Standardized Multi-Color Flow Cytometry and Computational Biomarker Discovery.- The Aryl Hydrocarbon Receptor in Immunity Tools and Potential.