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Small Molecules in Oncology

  • Kartonierter Einband
  • 238 Seiten
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Written by acknowledged experts, this text provides a broad overview of the small molecules currently used for the treatment of ma... Weiterlesen
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Beschreibung

Written by acknowledged experts, this text provides a broad overview of the small molecules currently used for the treatment of malignant diseases, and discusses interesting novel compounds that are in the process of clinical development to combat cancer.

Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.



Provides a broad overview of the small molecules currently used for the treatment of malignant diseases

Discusses interesting novel compounds that are in the process of clinical development to combat cancer

Written by acknowledged experts



Inhalt
Protein kinase inhibitors.- Imatinib Mesylate.- Erlotinib.- Axitinib (AG-013736).- Lapatinib.- Sorafenib.- Sunitinib.- Dasatinib.- Nilotinib.- Bosutinib.- Epigenetic modifiers.- Decitabine.- 5-Azacytidine/Azacitidine.- Cell cycle inhibitors.- Bortezomib.- Temsirolimus.- Danusertib (formerly PHA-739358) A Novel Combined Pan-Aurora Kinases and Third Generation Bcr-Abl Tyrosine Kinase Inhibitor.- BI_2536 - Targeting the Mitotic Kinase Polo-Like Kinase 1 (Plk1).- Other novel agents.- Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy.- GDC-0449 - Targeting the Hedgehog Signaling Pathway.

Produktinformationen

Titel: Small Molecules in Oncology
Editor:
EAN: 9783642261459
ISBN: 978-3-642-26145-9
Format: Kartonierter Einband
Herausgeber: Springer, Berlin
Genre: Medizin
Anzahl Seiten: 238
Gewicht: g
Größe: H235mm x B235mm x T155mm
Jahr: 2012
Auflage: Repr. d. Ausg. v. 2010

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