Satellites and Defective Viral RNAs

The nine chapters presented in this book provide contemporary reviews of research on defective RNAs, satellite RNA viruses, and dependent RNA viruses that require the presence of a helper virus in order to establish productive infections. Since their initial identification nearly four decades ago, fundamental analyses of pathogenic and interdependent interactions involving these agents have contributed enormously to our appreciation of virus structure, RNA replication, and processes leading to disease. Findings arising from these studies have also advanced numerous ancillary areas, including structure and function of nucleic acids and proteins, nucleoprotein interactions, translational mechan isms, RNA processing, macromolecular evolution, and a plethora of other specialty topics. Research on these subviral pathogens is continuing to illuminate various aspects of biology, chemistry, and biotechnology, so the book is intended to provide a current treatment that will be useful for readers with interests in topics related to these areas. Observations in the early I 960s first revealed that a defective virus, satellite tobacco necrosis virus (STNV), is associated with and depends on the presence of a hel per virus, tobacco necrosis virus (TNV), for its multiplication. This finding ushered in a new era in virology that soon resulted in a more profound apprecia tion of the relationships of viruses and their interactions with each other.

Klappentext

This volume provides an overview of a diverse array of defective RNA's associated with virus infections. These agents span a continuum ranging from parasitic to synergic. They include defective molecules with relatively simple genome organizations that depend on all of the functions encoded by their helper viruses, as well as complexes consisting of defective virus-like components that require only a single gene necessary for a critical function. Individual chapters by selected authorities in the field discuss the biology of these agents, their roles in disease development, the structural features and replicative mechanisms characteristic of each defective entity, and the functions supplied by their helper viruses.

Inhalt
List of Contents.- Defective and Defective Interfering RNAs of Monopartite Plus-strand RNA Plant Viruses.- Replication, Recombination, and Symptom-Modulation Properties of the Satellite RNAs of Turnip Crinkle Virus.- Structure and Functional Relationships of Satellite RNAs of Cucumber Mosaic Virus.- Large Satellite RNA: Molecular Parasitism or Molecular Symbiosis.- Encapsidated Circular Viroid-like Satellite RNAs (Virusoids) of Plants.- Human Hepatitis Delta Virus: an Agent with Similarities to Certain Satellite RNAs of Plants.- Biology and Structure of Plant Satellite Viruses Activated by Icosahedral Helper Viruses.- Satellite Tobacco Mosaic Virus.- Luteovirus-associated Viruses and Subviral RNAs.