Retinoids

In the future' the decade of the 1990s will likely be viewed as a Golden Age for retinoid research. There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop mental processes was first broadly recognized in the late 1980s. Between then and now, our knowledge of retinoid action has evolved from one of a near complete lack of understanding of how retinoids act within cells to one of sophisticated understanding of the molecular processes through which retinoids modulate transcription. In this volume, we have tried to provide a comprehensive update of the present understanding of retinoid actions, with an emphasis on re cent advances. The initial chapters of the volume, or Section A, focus on the physicochemical properties and metabolism of naturally occurring retinoids: - N OY provides an uncommonly encountered view of retinoid effects from the perspective of the physiochemical properties of retinoids. - V AKIANI and BUCK lend a perspective on the biological occurrence and actions of retro- and anhydro-retinoids. Section B considers both the retinoid nuclear receptors and their mechanisms of action as well as synthetic retinoids that have been used exper imentally to provide mechanistic insights into receptor actions and have potential therapeutic use for treating disease: - PIEDRAFITA and PFAHL provide a comprehensive review of retinoid nuclear receptor biochemistry and molecular biology.

This volume provides a state-of-the-art account of recent advances in retinoid research with major emphasis on metabolism, actions and pharmacologic aspects

Klappentext

This volume provides a state-of-the-art account of recent advances in the metabolism, actions and pharmacologic aspects of retinoid research and is the first comprehensive review in this rapidly moving research area. The chapters have a broad focus on the biologic uses and actions of retinoids and are written in a manner that will be useful both to readers with specialized research interests and those with only limited knowledge of this class of naturally occurring compounds and synthetic drugs Individual chapters deal with RAR and RXR specific agonists and antagonists, with retinoids in dermatology and oncology, with the physical properties of retinoids and how they affect retinoid actions, with retro-retinoic synthesis and functions, with the actions of retinoids in immunology and male reproduction.

Inhalt
Section A: Metabolism, Pharmocokinetics and Action of Retinoids.- 1 Physical-Chemical Properties and Action of Retinoids.- 2 Biosynthesis, Absorption, Metabolism and Transport of Retinoids.- 3 Retro-Retinoids: Metabolism and Action.- 4 Retinoic Acid Synthesis and Metabolism.- Section B: Binding Proteins and Nuclear Receptors.- 5 Nuclear Retinoid Receptors and Mechanisms of Action.- 6 RAR-Selective Ligands: Receptor Subtype and Function Selectivity.- 7 RXR-Speeific Agonists and Modulators: A New Retinoid Pharmacology.- Section C: Differentiation, Proliferation, and Cancer.- 8 Growth Control by Retinoids: Regulation of Cell Cycle Progression and Apoptosis.- 9 Retinoids and Differentiation of Normal and Malignant Hematopoietic Cells.- 10 The Retinoids: Cancer Therapy and Prevention Mechanisms.- 11 Aberrant Expression and Function of Retinoid Receptors in Cancer.- Section D: Development and Teratogenesis.- 12 Genetic and Molecular Approaches to Understanding the Role of Retinoids in Mammalian Spermatogenesis.- 13 The Role of Retinoids in Vertebrate Limb Morphogenesis: Integration of Retinoid- and Cytokine-Mediated Signal Transduction.- 14 Retinoids in Neural Development.- 15 Avian Embryo as Model for Retinoid Function in Early Development.- 16 Retinoid Receptors, Their Ligands, and Teratogenesis: Synergy and Specificity of Effects.- Section E: Skin.- 17 Vitamin A Homeostasis in Human Epidermis: Native Retinoid Composition and Metabolism.- 18 New Concepts for Delivery of Topical Retinoid Activity to Human Skin.- 19 Retinoid Receptor-Selective Agonists and Their Action in Skin.- Section F: Special Effects.- 20 Retinoids in Mammalian Vision.- 21 Retinoids and Immunity.