Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors

Scientific advances over the past two decades have afforded unprecedented oppor tunities to understand the structure and function of receptors, receptor-ligand interactions, and receptor signaling. The extent ofprogress in this area is underscored by the recent Nobel Prize for Medicine and Physiology to Alfred Gilman and Martin Rodbell, both of whose work in understanding receptorlG-protein interactions has redefined the way in which we think of how hormones and neurochemicals exert their activity on cellular function. This book is replete with examples of current research approaches to help us better understand the cellular roles in which the renin-angiotensin system and the angiotensin receptors participate. Clearly, defining the structure of angiotensin receptor subtypes is an important first step in cJarifying the mechanisms by which these receptors take part in cellular function. However, the chapters within this book range far beyond structural studies and encompass research on tissue specific expression of the angiotensin receptor subtypes, the genetic regulation ofthese receptors, and the unique function ofvarious angiotensin subtypes in different organ systems, such as the brain, the reproductive system, adipose tissue, the heart, and the kidneys.

Inhalt

1. Characterization of a cis-Regulatory Element and trans- Acting Protein That Regulates Transcription of the Angiotensin II Type 1A Receptor Gene.- 2. Human AT1 Receptor Gene Regulation.- 3. Regulation of Gene Transcription of Angiotensin II Receptor Subtypes in the Heart.- 4. Sodium Induced Regulation of Angiotensin Receptor 1A and 1B in Rat Kidney.- 5. Characterization and Regulation of Angiotensin II Receptors in Rat Adipose Tissue: Angiotensin Receptors in Adipose Tissue.- 6. Changes in Angiotensin AT1 Receptor Density during Hypertension in Fructose-Fed Rats.- 7. Cardiac Effects of AII: AT1A Receptor Signaling, Desensitization, and Internalization.- 8. AT1-Receptors and Cellular Actions of Angiotensin II in Neuronal Cultures of Stroke Prone-Spontaneously Hypertensive Rat Brain.- 9. Antisense Oligonucleotides for in Vivo Studies of Angiotensin Receptors.- 10. Interactions of Angiotensin II with Central Dopamine.- 11. Regulation of the Hypothalmic-Pituitary-Adrenal Axis and Vasopressin Secretion: Role of Angiotensin II.- 12. Relationship between the Drinking Response to Angiotensin II and Induction of fos in the Brain.- 13. Identification of AT1 Receptors on Cultured Astrocytes.- 14. Structure-Activity Relationship of the Agonist-Antagonist Transition on the Type 1 Angiotensin II Receptor; the Search for Inverse Agonists.- 15. Molecular Cloning and Expression of Angiotensin II Type 2 Receptor Gene.- 16. Molecular Cloning of the Human AT2 Receptor.- 17. Molecular and Functional Characterization of Angiotensin II AT2 Receptor in Neuroblastoma N1E-115 Cells.- 18. Characterization of the AT2 Receptor on Rat Ovarian Granulosa Cells.- 19. AT2 Receptor Expression in Ovaries: A Review.- 20. Heterogeneity of Rat Angiotensin II AT2 Receptor.- 21. Heterogeneity of AngiotensinType 2 (AT2) Receptors.- 22. Angiotensin II Stimulates Protein Phosphatase 2A Activity in Cultured Neuronal Cells via Type 2 Receptors in a Pertussis Toxin Sensitive Fashion.- 23. Functional Aspects of Angiotensin Type 2 Receptor.- 24. Angiotensin Receptor Heterogeneity in the Dorsal Medulla Oblongata as Defined by Angiotensin-(17).- 25. Atypical (Non-AT1, Non-AT2) Angiotensin Receptors.- 26. Brain Angiotensin II and Related Receptors: New Developments.- 27. Receptors for (38) Angiotensin in Brain Cells: AngIV Binding in Brain Cells.