Design & Evaluation of Controlled Release Matrix Tablets of Prazosin

In the present study, we have prepared matrix tablet formulations using Prazocin as a model drug and Ethyl Cellulose, Two grades of Hydroxy Propyl Methyl Cellulose- HPMC-K4M & HPMC-K100M as polymers in different ratios. The developed matrix tablets were evaluated for different physical-chemical evaluations like drug content, hardness, friability, swelling index etc. All the formulations had shown the results within prescribed limits. The In vitro drug release study indicates that formulation PCF-7 containing EC, HPMC K100M in 1:2 ratio shown good release pattern for 14 hours compares to other formulations. The short-term stability study proved no change in the formulation of ageing and it indicates good stability.

Autorentext

Mr. Rajan Kothari, M.Pharm.(Pharmaceutics), Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka, India. Assistant Professor at Faculty of Pharmaceutical Sciences, Mewar University, Gangrar, Chittorgarh-312901, Rajasthan, India