Klappentext

Proteostasis and Cancer explores the intricate mechanisms of protein homeostasis and their critical roles in cancer progression and therapeutics. This comprehensive volume is designed to provide graduate students, researchers, and medical students with a thorough understanding of proteostatic processes and their involvement in cancer. The book delves into the mechanisms that control proteins inside the cell to preserve the health of the cellular proteome and the organism itself. It covers key topics such as post-translational modifications, protein folding, proteolysis, and the unfolded protein response (UPR), with a specific focus on their roles in cancer. Detailed discussions on molecular chaperones, the ubiquitin-proteasome system, and autophagy pathways offer valuable insights into how these processes contribute to cancer progression and how they can be targeted for therapeutic interventions. With clear explanations and well-labeled diagrams, the book makes complex concepts accessible to students and researchers alike. It also addresses the clinical implications of proteostasis in cancer, providing a foundation for developing innovative therapeutic strategies. The book's multidisciplinary approach, combining insights from biochemistry, cancer biology, and medical sciences, makes it an essential resource for anyone seeking to understand the role of proteostasis in cancer. This volume serves as a valuable reference for scientists and researchers working in the field of protein biology and cancer, offering up-to-date research information and comprehensive insights into host-pathogen interactions. It equips readers with the knowledge necessary to design better mitigation strategies against cancer, fostering interdisciplinary collaborations and advancing the field of cancer research.

Inhalt

1. An overview of Proteostasis or Protein Homeostasis
   
   2. Post-translational modifications, protein folding and Proteolysis
   3. Protein misfolding, Endoplamsic reticulum stress and Unfolded Protein Response (UPR)
   4. Proteostasis and Human diseases
   5. Methodology to study Proteostasis
   6. Molecular Chaperones in Cancer
   7. Mitochondrial Proteostasis, UPR and Cancer
   8. Ubiquitin-proteasome system and its role in Cancer
   9. Proteostasis and Autophagy pathways in Cancer
   10. Role of Proteostasis in Breast cancer
   11. Proteostasis in solid tumors
   12. Proteostasis and liquid or blood cancer
   13. How Proteostasis can be targeted in cancer: therapeutic perspective.
   14. Clinical implications of Proteostasis in Cancer