Progress in Radiopharmacology 1985

This volume is based upon presentations made to the 4th European Symposium on Radiopharmacology which was held under the auspices of the European Joint Committee on Radiopharma ceuticals (ENMS / SNME) in Athens from March 28 - 31, 1984. The Medical Insurance Foundation of the National Bank of Greece (TYPET) sponsored this meeting and the Joint Committee would like to express their gratitude to the local organising committee: G. Limouris, M. Pierroutsakou, A. Sarris, A. Tzoulis and C. Binas. A word of thanks also to Mrs. Tineke Busker who prepared the camera ready copy. The meeting reflects the continuing and growing interest in biodistribution and factors which can influence bio distribution in the clinical situation. The choice of sub jects, respiration, cerebral function, biodistribution and metabolism complement earlier volumes in this series and reflect European interests in these areas. P. H. Cox Rotterdam, April 1985 VII CONTENTS Foreword P. H. Cox v Contributors XI I. THE RESPIRATORY SYSTEM Physiology and pathophysiology of the respiratory system J. Roth, E. Henze, W. E. Adam 3 Generator-produced Krypton-81m in gas and liquid phases for medical applications M. Guillaume, N. Garzaniti, H. Zicot, T. Khuc, P. Bartsch 23 Noble radionuclides for lung ventila tion studies I. Bofilias 49 Radioaerosols in nuclear medicine M. Pillay, B. Shapiro, P. H. Cox 57 99m A dry aerosol of Tc -albuminmilli micro spheres for lung ventilation scintigraphy: preparation, inhalation apparatus and examples of clinical results P. Angelberger, I. Zolle, A. Strigl, H. Kahn, A. Mostbeck, W.

Inhalt
I. The Respiratory System.- Physiology and pathophysiology of the respiratory system.- Generator-produced Krypton-81m in gas and liquid phases for medical applications.- Noble radionuclides for lung ventilation studies.- Radioaerosols in nuclear medicine.- A dry aerosol of Tc99m-albuminmilli-microspheres for lung ventilation scintigraphy: preparation, inhalation apparatus and examples of clinical results.- II. Cerebral Function.- New agents for probing glucose turnover and receptor densities in the brain.- Cerebral uptake of radioiodinated amphetamines basic research and clinical results.- Radiolabelled Schiff bases in brain studies.- III. Biodistribution and Metabolism of Radiopharmaceuticals.- Some recent progress in the development and application of radiopharmaceuticals labelled with 11C and 18F.- Radiopharmaceuticals suitable for cardiac emergency studies.- The pharmacokinetics of Tc99m-diethyl ida in hyperferremic mice.- Subcellular distribution of Tc99m Sn-phytate in the liver of rats.- Treatment of thyroid disorders by 131I.- IV. Extraneous Factors Affecting Biodistribution.- Alterations in the biodistribution of radiopharmaceuticals, caused by extraneous influences.- The effects of drugs and therapeutic procedures on the biodistribution of skeletal reagents.- Interaction between some disinfectants and Tc99m-radiopharmaceuticals.- Altered uptake of Tc99m-MDP, Ca47 and Ga67 by mice osteogenic sarcoma after administration of a cytostatic drug.- Visualisation of gallbladder and gut on Tc99m bone scintiscans.- Drug-free high-quality tumour imaging with 67Ga.- Author index.