Prodrug

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High Quality Content by WIKIPEDIA articles! A prodrug is a pharmacological substance (drug) that is administered in an inactive (o...

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High Quality Content by WIKIPEDIA articles! A prodrug is a pharmacological substance (drug) that is administered in an inactive (or significantly less active) form. Once administered, the prodrug is metabolised in vivo into an active metabolite. The rationale behind the use of a prodrug is generally for absorption, distribution, metabolism, and excretion (ADME) optimization. Prodrugs are usually designed to improve oral bioavailability, with poor absorption from the gastrointestinal tract usually being the limiting factor.