Post-Traumatic Arthritis

Bringing together the most up-to-date research on post-traumatic arthritis (PTA) and its management, this book is a comprehensive presentation of the current thinking on all aspects of the mechanisms of joint injury and subsequent development of PTA. Divided into thematic sections, it includes discussions of the incidence and burden of PTA, both in society at large and in the military population specifically; the relevant experimental work on PTA, from basic science to animal models; peri-articular tissue responses to of joint injury and potential mechanisms of PTA; the current clinical assessment and treatment of common joint injuries leading to PTA; and emerging technologies and treatments for PTA, including biomarkers and stem cell therapies. Taken together, it will be an invaluable resource for orthopedic surgeons, rheumatologists and other joint injury researchers and clinicians.

Provides a comprehensive, up-to-date discussion of the current thinking on joint injury and post-traumatic arthritis Presents the incidence and burden of PTA, basic science and animal-based models, potential mechanisms and clinically applicable management techniques Assesses emerging technologies and treatments for PTA, including biomarkers and stem cell therapy Includes supplementary material: sn.pub/extras

Autorentext

Steven A. Olson, MD, Professor, Duke University Medical Center, Department of Orthopaedic Surgery, Durham, NC, USA

Farshid Guilak, PhD, Laszlo Ormandy Professor, Duke University Medical Center, Department of Orthopaedic Surgery, Durham, NC, USA

Inhalt
Section I: The Problem of Post-Traumatic Arthritis.- Arthritis that Develops after Joint Injury: Is it Post-Traumatic Arthritis or Post-Traumatic OsteoArthritis?.- Post-Traumatic Arthritis: Definitions and Burden of Disease.- Arthritis after Joint Injury: The Military Experience.- Section II: Experimental Models of Joint Injury.- In Vitro Cartilage Explant Injury Models.- Animal Models of Meniscal Injury in Post-Traumatic Arthritis.-Anterior Cruciate Transection/Disruption Models of Posttraumatic Arthritis.- Closed Joint ACL Disruption Murine Model of PTA.- Whole Joint Models of Articular Injury and Articular Fracture.- Instability: Dynamic Loading Models.- Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question.- Section III: Peri-articular Tissue Response to Joint Injury.- The Response of Cartilage to Injury.- The Response of Subchondral Bone to Injury.- Genetic Variability in the Response to Injury.- Aging and Post-Traumatic Arthritis.-Potential Mechanisms of PTA: Cell Death.- Potential Mechanisms of PTA: Inflammation.- Potential Mechanisms of PTA: Oxidative Stress.- Potential Mechanisms of PTA: Alterations in Joint Loading.- Section IV: Clinical Assessment and Treatment of Patients with Joint Injury.- Imaging Specific to Cartilage Injury.- Outcomes of ACL Injury: The MOON Consortium.- Current Treatment and Outcomes of Intra-articular Fractures.- Non-arthroplasty Treatments for PTA in the Lower Extremity.- Results of Arthroplasty in Post-Traumatic Arthritis.- Section V: Developing and Future Assessment and Therapies.- Measurement of Severity of Injury after Articular Fracture and Correlation with Post-Traumatic Arthritis Development.- Biomarkers of PTA.- Potential Targets for Pharmacologic Therapies for Prevention of PTA.- Stem Cells Therapies for Post-Traumatic Arthritis.- Unanswered Questions and Future Directions.