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Formulation of Self Microemulsifying Drug Delivery System

  • Kartonierter Einband
  • 108 Seiten
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In this book, a method to prepare self-microemulsifying drug delivery system (SMEDDS) of the poorly water-soluble drugcefadroxil m... Weiterlesen
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Beschreibung

In this book, a method to prepare self-microemulsifying drug delivery system (SMEDDS) of the poorly water-soluble drugcefadroxil monohydrate is explained. The impact of the oil, surfactant and co-surfactant on the drug solubility and their ratios on forming efficient and stable SMEDDS were examined. Water titration method was used to formulation of SMEDDS. The SMEDDS were characterized by morphological observation, globule size, cloud point measurement,viscosity determination,refractive index,% transmittance, drug content of SMEDDS of cefadroxil monohydrate and in vitro release study. The optimum formulation F2 consisted of oleic acid, tween-80 and PEG-400 with S mix. ratio of 1:1. In vitro release test showed a complete release of cefadroxil monohydrate from SMEDDS in an approximately 1.5hr. SMEDDS cefadroxil monohydrate oral formulations were prepared that provide excellent drug solubilization and improved in vitro release of cefadroxil monohydrate compare to marked product. The selected formulation F2 was tested for pharmacokinetic studies in comparison to marketed formulation it showed increase in the oral bioavailability of cefadroxil monohydrate.

Autorentext

Dr. Popat B. Mohite is working as Associate Professor and Head in Department of Pharmaceutical Chemistry & PG studies at MES's College of Pharmacy, Sonai. He published 72 publication in National & international journals of repute. He has guided 12 M. Pharm students. He is life time member of APTI.

Produktinformationen

Titel: Formulation of Self Microemulsifying Drug Delivery System
Untertitel: SMEDDS of Antibiotic
Autor:
EAN: 9786202058360
ISBN: 6202058366
Format: Kartonierter Einband
Herausgeber: LAP LAMBERT Academic Publishing
Genre: Medizin
Anzahl Seiten: 108
Gewicht: 179g
Größe: H220mm x B150mm x T6mm
Jahr: 2017
Untertitel: Englisch