Autorentext
Subrata Pal obtained his bachelor's and master's degrees, both in physics, from Calcutta University. Subsequently, he pursued his predoctoral research in molecular biology and received a PhD degree from the same university in 1982. He carried out his postdoctoral research in DNA replication and gene expression at two of the premiere institutions in the USA: the National Institutes of Health, Bethesda, Maryland and Harvard Medical School, Boston Massachusetts. At Harvard, he received a Claudia Adams Barr special investigator award for basic contribution to cancer research. Professor Pal has a long teaching experience at the undergraduate and graduate levels the areas of his teaching include physics, molecular biology and genomics.

Klappentext

Fundamentals of Molecular Structural Biology, Second Edition reviews the mathematical and physical foundations of molecular structural biology, covering the latest advancements in the field. The book begins with a historical perspective before exploring a range of topics including mathematical concepts, physical aspects of chemistry, chemical basis of biology, structural analysis and visualization, protein folding, transcription, RNA processing, cell signaling, and computational molecular biology. Additionally this new edition delves into AI fundamentals and applications, including AlphaFold and RoseTTAFold. In recent years AI has made a big impact upon molecular structural biology, and this book explores the latest developments in this area. This fully updated edition provides a detailed overview of the fundamental concepts across molecular structural biology and acts as an ideal guide for researchers and advanced students working in this area. Given the increasingly interdisciplinary nature of this subject, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche.

Inhalt

1. Introduction: A historical perspective
   
   2. Mathematical preliminaries
   3. Physical basis of chemistry
   4. Chemical basis of biology
   5. Biomacromolecules
   6. Structure analysis and visualization
   7. Protein Folding
   8. DNA synthesis: Replication
   9. Transcription
   10. RNA processing
   11. Translation
   12. DNA damage and repair
   13. Recombination
   14. Membrane structure and function
   15. Fundamentals of structural genomics
   16. Cell signaling and systems biology
   17. Macromolecular assemblies
   18. Computational molecular biology
   19. Artificial intelligence (AI) applications