A Network-Based Approach to Cell Metabolism

Nominated as an outstanding Ph.D. thesis by the University of Barcelona, Spain

Unveils new mechanisms and responses impossible to demonstrate with by traditional reductionist procedures

Has given rise to a large number of articles in scholarly journals

Nominated as an outstanding Ph.D. thesis by the University of Barcelona, Spain Unveils new mechanisms and responses impossible to demonstrate with by traditional reductionist procedures Has given rise to a large number of articles in scholarly journals Includes supplementary material: sn.pub/extras

Autorentext

Oriol Güell holds a Ph.D. in Physical Chemistry from the University of Barcelona, Spain, and has broad experience in the theoretical modelling and the experimental applications of magnetic colloidal dispersions and in the computer modelling of metabolic networks. Currently, his main research focuses on obtaining and applying bio-based polymers and plasticisers and studying their associated physicochemical properties.

Inhalt

Cellular Metabolism at the Systems Level.- Methods and Data.- Structural Knockout Cascades in Metabolic Networks.- Eects of Reaction Knockouts on Steady States of Metabolism.- Detection of Evolution and Adaptation Fingerprints in Metabolic Networks.- Assessing FBA Optimal States in the Feasible Flux Phenotypic Space.- Conclusions.