Mouse Models for Drug Discovery

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As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to...

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As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.
Provides an excellent source for understanding the strength of the mouse as a model Includes essential background about mouse genetic engineering Covers the classic outbred and inbred mice as well as the latest genetically engineered mouse models Surveys a wide range of mouse human disease models Presents guidance from experimental design, techniques, and approaches to data analysis Describes the power of humanized mouse models Highlights thorough protocols and techniques accompanied by useful illustrations as provided by experts in the field Includes supplementary material: sn.pub/extras
Inhalt
1. Improving Toxicity Screening and Drug Development by Using Genetically Defined Strains Michael F.W. Festing 2. The Sophisticated Mouse: Protecting a Precious Reagent Michael V. Wiles and Rob A. Taft 3. Genetically Engineered Mouse Models in Drug Discovery Research Rosalba Sacca, Sandra J. Engle, Wenning Qin, Jeffrey L. Stock, and John D. McNeish 4. Engineering the Mouse Genome to Model Human Disease for Drug Discovery Frank Koentgen, Gabriele Suess, and Dieter Naf 5. Profiling of Drug Action Using Reporter Mice and Molecular Imaging Gianpaolo Rando, Andrea Biserni, Paolo Ciana, and Adriana Maggi 6. Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies Derry C. Roopenian, Gregory J. Christianson, and Thomas J. Sproule 7. Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease Steve Pino, Michael A. Brehm, Laurence Covassin-Barberis, Marie King, Thomas H. Chase, Jennifer Wagner, Lisa Burzenski, Oded Foreman, Dale L. Greiner, and Leonard D. Shultz 8. Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans David V. Serreze, Marijke Niens, John Kulik, and Teresa P. DiLorenzo 9. Mouse Models of Type II Diabetes Mellitus in Drug Discovery Helene Baribault 10. Cholesterol Absorption and Metabolism Philip N. Howles 11. Collagen-Induced Arthritis in Mice Lisette Bevaart, Margriet J. Vervoordeldonk, and Paul-Peter Tak 12. Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening John P. Sundberg, Kathleen A. Silva, Caroline McPhee, and Lloyd E. King, Jr. Characterization and Treatment of Epidermolysis Bullosa Jason A. Bubier, Thomas J. Sproule, John P. Sundberg, and Derry C. Roopenian 14. Models of Metastasis in Drug Discovery James E. Talmadge 15. Methods for Evaluating Effects of an Irinotecan + 5-Fluorouracil/ Leucovorin (IFL) Regimen in an Orthotopic Metastatic Colorectal Cancer Model Utilizing In Vivo Bioluminescence Imaging David Surguladze, Philipp Steiner, Marie Prewett, and James R. Tonra 16. CML Mouse Model in Translational Research Cong Peng and Shaoguang Li 17. Mouse Models for Studying Depression-Like States and Antidepressant Drugs Carisa L. Bergner, Amanda N. Smolinsky, Peter C. Hart, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte, and Allan V. Kalueff 18. Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors Amy W. Lasek and Nourredine Azouaou 19. Experimental Models of Anxiety for Drug Discovery and Brain Research Peter C. Hart, Carisa L. Bergner, Amanda N. Smolinsky, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte, and Allan V. Kalueff 20. Mouse Models of Neurodegenerative Diseases: Criteria and General Methodology Christopher Janus and Hans Welzl 21. Neuromuscular Disease Models and Analysis Robert W. Burgess, Gregory A. Cox, and Kevin L. Seburn 22. Murine Model of Pneumococcal Pneumonia Eva Medina 23. Murine Model of Cutaneous Infection with Streptococcus pyogenes Eva Medina 24. Murine Model of Polymicrobial Septic Peritonitis Using Cecal Ligation and Puncture (CLP) Eva Medina