Molecular Mechanisms Controlling Transmembrane Transport

All living cells are strictly separated from their surroundings by a membranous lipid bilayer. Into these membranes a variety of transport proteins are embedded that ensure the uptake and secretion of various molecules and ions. In order to respond properly to a changing nutrient supply or demand, as well as to external stress factors, cells must be able to adapt both amount and activity of the corresponding transporters. This book provides readers with state-of-the-art knowledge on the various regulatory mechanisms that control transmembrane transporter expression, activity and their subcellular localisation.

Comprehensively covers transporter regulation in bacteria, yeast, plant and animal cells

Autorentext
Reinhard Krämer is chair in Biochemistry at Cologne University, Germany. After studying Biochemistry at the Universities of Tübingen and Munich, he obtained his Ph.D. from LMU Munich. He then spent 10 years at the Research Center Jülich (Institute of Biotechnology) and the University of Düsseldorf as an Associate Professor for Biochemistry before taking up his present position at Cologne University. During his scientific career, R. Krämer has focused on different aspects of membrane transport proteins, both in mitochondria and in prokaryotes, as well as on stress response in bacteria, in particular osmotic stress.

Inhalt

Role of Transporter-like Sensors in Glucose and Amino Acid Signalling in Yeast.- Transcriptional Regulation of Intestinal Nutrient Transporters.- Transport-Dependent Gene Regulation by Sequestration of Transcriptional Regulators.- Regulation of Carrier-mediated Sugar Transport by Transporter Quaternary Structure.- Regulation and Function of Ammonium Carriers in Bacteria, Fungi, and Plants.- Osmoregulation and Osmosensing by Uptake Carriers for Compatible Solutes in Bacteria.- The Bacterial Phosphotransferase System: a Perfect Link of Sugar Transport and Signal Transduction.- Ancillary Proteins in Membrane Targeting of Transporters.- Regulation of Transporter Trafficking by the Lipid Environment.- Trafficking of Vesicular Transporters to Secretory Vesicles.- Regulated Transport of the Glucose Transporter GLUT4.- Molecules in Motion: Multiple Mechanisms that Regulate the GABA Transporter GAT1.- Generation of Transporter Isoforms by Alternative Splicing.- Membrane Trafficking of Yeast Transporters: Mechanisms and Physiological Control of Downregulation.