Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

The NATO Advanced Study Institute of "Molecular and Applied Aspects of Oxida tive Drug Metabolizing Enzymes" was held in Tekirova, Antalya, Turkey, from August 31 to September 11, 1997. This Institute was the third of a series of the NATO ASIs on a similar topic relating to the enzymes of oxidative metabolism of xenobiotics. The first NATO ASI in this series, entitled "Molecular Aspects of Monooxygenases and Bioactiva tion of Toxic Compounds" (NATO ASI Series A: Life Sciences, Vol. 202), was held in

Klappentext

Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997

Zusammenfassung
Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997

Inhalt

1. The Fate of Xenobiotics in the Body: Enzymes of Metabolism.- 2. Protein-Protein Interactions in the P450 Monooxygenase System.- 3. Structures of Mitochondrial P450 System Proteins.- 4. Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs).- 5. Expression and Regulation of Flavin-Containing Monooxygenases.- 6. Correlations between in Vivo and in Vitro Studies in Human Drug Metabolism.- 7. Pharmacogenetics: Polymorphisms in Xenobiotic Metabolism.- 8. Clinical Aspects of Polymorphic Drug Metabolism in Humans.- 9. Genetic Polymorphisms of Cytochromes P450 1 A1 and 2E1 and of Glutathione S-Transferase M1 and Cancer Susceptibility in the Human.- 10. Cytochrome P450 Isoforms: Insecticide Metabolism in Insects and Mammals and Role in Insecticide Resistance.- 11. Inhibitors of CYP51 as Antifungal Agents and Resistance to Azole Antifungals.- 12. The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicity.- 13. Importance of Drug Metabolism in Drug Discovery and Development.- 14. Aflatoxin Biotransformation and Toxicology.- 15. Role of Individual Enzymes in the Control of Genotoxic Metabolites.- 16. Enhancement of the Mutagenicity of Ethylene Oxide and Several Directly Acting Mutagens by Human Erythrocytes and Its Reduction by Xenobiotic Interaction.- 17. Cytochrome P4501 Al (Cyp 1A1) and Associated MFO Activities in Fish as an Indicator of Pollution with Special Reference to Izmir Bay.- 18. Cyp 1A Concentrations as an Indicator of Exposure of Fish to Pulp-Mill Effluents.- 19. The Biochemistry and Physiology of Prostacyclin- and Thromboxane-Synthase.- 20. Cell Engineering of the Rat and Human Cysteine Conjugate Beta Lyase Genes and Applications to Nephrotoxicity Assessment.