Anti-cancer effects of -mangostin on human breast cancer cell lines

In this book, -mangostin (AM), a xanthone compound was investigated for its apoptosis mechanism on MCF-7 and MDA-MB-231 cell lines. The treatment of the cells with AM prompted apoptosis with cell death-transducing signals. This type of apoptosis was suggested to occur through the both extrinsic and intrinsic pathways and prevention of translocation of NF- B from the cytoplasm to the nucleus. Our results revealed AM prompt apoptosis of the both cells through NF- B, Bax/Bcl-2 and HSP70 protein modulation with the contribution of caspases. Therefore, AM is deemed to have considerable potential in the control of breast cancer.

Autorentext

Mohamed Yousif Ibrahim Dafalla is a postdoctoral researcher at University of Malaya. He obtained his Bachelor in Veterinary Medicine from University of Khartoum, Sudan in 2003. He finished his master at University Putra Malaysia. He was involved in the pharmacological research.He has obtained PhD in Pharmacology from University of Malaya in 2015.