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This volume details methods and protocols for the synthesis and characterization of glycopolymers and their biomedical application... Weiterlesen
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This volume details methods and protocols for the synthesis and characterization of glycopolymers and their biomedical applications. Chapters are divided into three parts covering synthesis and characterization of glycopolymers; glycopolymer-nanoparticle conjugates; and surface immobilized glycopolymers. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Macro-Glycoligands: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Includes cutting-edge methods and protocols

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from the experts

Part I: Synthesis and Characterization of Glycopolymers 1. Synthesis of Chain-end Functionalized Glycopolymers via Cyanoxyl Mediated Free Radical Polymerization (CMFRP)Valentinas Gruzdys, Jinshan Tang, Elliot Chaikof, Xue-Long Sun 2. Protecting-group-free Synthesis of Well-defined Glycopolymers Featuring Negatively Charged OligosaccharidesLuca Albertin 3. Glycopolymers Prepared by Ring-opening Metathesis Polymerization Followed by Glycoconjugation Using a Triazole Forming 'Click' ReactionRonald Okoth and Amit Basu 4. Protecting-group-free Synthesis of Glycopolymers and Their Binding Assay with Lectin and Influenza VirusTomonari Tanaka, Tadanobu Takahashi, and Takashi Suzuki 5. Carbohydrate-based Initiators for the Cationic Ring-opening Polymerization of 2-Ethyl-2-oxazolineChristine Weber,Michael Gottschaldt, Richard Hoogenboom, Ulrich S. Schubert 6. Heterofunctional Glycopolypeptides by Combination of Thiol-ene Chemistry and NCA PolymerizationKai-Steffen Krannig and Helmut Schlaad 7. Preparation of Proteoglycan Mimetic Graft CopolymersMatt J. Kipper and Laura W. Place Part II: Glycopolymer Nanoparticle Conjugates 8. Galactosylated Polymer Nano-objects by Polymerization-Induced Self-Assembly, Potential Drug NanocarriersMona Semsarilar, Irene Canton, and Vincent Ladmiral 9. Synthetic Approach to Biotinylated Glyco-Functionalized Quantum Dots: A New Fluorescent Probes for Biomedical ApplicationsChristian K. Adokoh, James Darkwa, and Ravin Narain 10. Surface Modification of Polydivinylbenzene Microspheres with a Fluorinated Glycopolymer using Thiol-Halogen Click ChemistryWentao Song and Anthony M. Granville 11. Glycopolymer-grafted Polymer Particles for Lectin RecognitionMichinari Kohri, Tatsuo Taniguchi, and Keiki Kishikawa 12. Synthesis of Non-spherical Glycopolymer-decorated Nanoparticles: Combing Thiol-ene with Catecholic ChemistryXiao Li, Weidong Zhang,and Gaojian Chen 13. Synthetic Approach To Glycopolymer Base Nanoparticle Gold(I) Conjugate: A New Generation Of Therapeutic AgentsChristian K. Adokoh, James Darkwa, and Ravin Narain 14. Multivalent Glycopolymer-coated Gold NanoparticlesSarah-Jane Richards, Caroline I. Biggs, and Matthew I. Gibson Part III: Surface Immobilized Glycopolymers 15. Modulation of Multivalent Protein Binding on Surfaces by Glycopolymer Brush Chemistry Kai Yu, A. Louise Creagh, Charles A. Haynes, Jayachandran N. Kizhakkedathu 16. Oriented Immobilized Sialyloligo-Macroligand MicroarraySatya Nandana Narla and Xue-Long Sun 17. Glycocalyx Remodeling with Glycopolymer-based Proteoglycan MimeticsMia L. Huang, Raymond A. A. Smith, Greg W. Trieger, and Kamil Godula


Titel: Macro-Glycoligands
Untertitel: Methods and Protocols
EAN: 9781493949489
ISBN: 1493949489
Format: Kartonierter Einband
Herausgeber: Springer New York
Anzahl Seiten: 240
Gewicht: 460g
Größe: H254mm x B178mm x T13mm
Jahr: 2016
Auflage: Softcover reprint of the original 1st ed. 2016

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