Beschreibung

As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In this book, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. They provide cutting-edge analysis of the most up-to-date and preeminent information available.

Chapters written by world-renowned leaders in the field of gene-mapping

A clear synthesis of all important methodology that has been developed in tis complex research field

Cutting-edge analysis of the most up-to-date and preeminent information available

Inhalt
LINKAGE DISEQUILIBRIUM AND ASSOCIATION MAPPING: ANALYSIS AND APPLICATIONS. Chapter 1. Linkage disequilibrium and association mapping - an introduction. (Andrew Collins). Chapter 2. A history of association mapping (Newton E Morton) . Chapter 3. Linkage disequilibrium maps and location databases.(William Tapper). Chapter 4. LDMAP: The construction of high-resolution linkage disequilibrium maps of the human genome. (Kuo T-Y, Lau W, Collins A). Chapter 5. Linkage disequilibrium as a tool for detecting the signatures of selection. (Sarah Ennis) . Chapter 6. The genetic basis of complex traits - rare variants or 'common gene common disease'? (Sudha K Iyengar, Robert C Elston ). Chapter 7. Linkage Disequilibrium Mapping for Complex Disease Genes (Andrew DeWan, Robert J. Klein, Josephine Hoh). Chapter 8. Linkage disequilibrium maps and disease association mapping (Nik Maniatis). Chapter 9. Coalescent methods for fine-scale disease gene mapping (Andrew P. Morris). Chapter 10. Family Based Linkage Disequilibrium Tests Using general pedigrees (Yin Yao Shugart, Lina Chen, Terri Beaty). Chapter 11. Association studies using familial cases: an efficient strategy for identifying low penetrance disease alleles (Emily L. Webb, Richard S. Houlston). Chapter 12. Association mapping using pooled DNA (Hsin-Chou Yang and Cathy S. J. Fann). Chapter 13. Selecting SNPs for Association Studies with SNPbrowser™ Software (Francisco M. De La Vega) Chapter 14. Avoiding false discoveries in association studies (Chiara Sabatti). Chapter 15. Gene mapping in asthma related traits. (Tarja Laitinen). Chapter 16. Identifying susceptibility variants for type 2 diabetes. (Eleftheria Zeggini and Mark I McCarthy).

Produktinformationen

Titel:	Linkage Disequilibrium and Association Mapping
Untertitel:	Analysis and Applications
Editor:	Andrew R. Collins
EAN:	9781617377099
ISBN:	978-1-61737-709-9
Format:	Kartonierter Einband
Herausgeber:	Springer, Berlin
Genre:	Medizin
Anzahl Seiten:	255
Größe:	H229mm x B229mm x T152mm
Jahr:	2010
Untertitel:	Englisch
Auflage:	Softcover reprint of hardcover