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Lacrimal Gland, Tear Film, and Dry Eye Syndromes

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During the past decade a significant international research effort has been directed towards understanding the composition and reg... Weiterlesen
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During the past decade a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays an essential role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in countless individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perforation of the cornea, an increased incidence of infectious disease, and potentially, pronounced visual disability and blindness. 7 To promote further progress in this field of vision research, the International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance was held in the Southampton Princess Resort in Bermuda from November 14 to 17, 1992. This meeting was designed to assess critically the current knowledge and 'state of the art' research on the structure and function of lacrimal tissue and tears in both health and disease. The goal of this conference was to provide an international exchange of information that would be of value to basic scientists involved in eye research, to physicians in the ophthalmological community, and to pharmaceutical companies with an interest in the treatment of lacrimal gland, tear film or ocular surface disorders (e. g. Sjogren's syndrome).


Proceedings of the International Conference on [title], held in Southampton, Bermuda, November 1992. Following the keynote address (Regulation of Tear Secretion by D.A. Dartt), the volume covers: lacrimal gland anatomy and innervation/ electrophysiology, water and ion transport/signal transduction

Keynote Address.- Regulation of Tear Secretion.- Lacrimal Gland: Anatomy and Innervation.- The Anatomy and Innervation of Lacrimal Glands.- Light and Electron Microscopic Morphology of Accessory Lacrimal Glands.- Immunohistochemistry and Protein Secretion in the Rat Lacrimal Gland: A Morphophysiological Study.- Carbonic Anhydrase and Acinar Cell Heterogeneity in Rat and Rabbit Lacrimal Glands.- Basement Membrane Modulation of Stimulated Secretion by Lacrimal Acinar Cells.- Galactose-Binding Sites in the Acinar Cells of the Human Accessory Lacrimal Gland.- Thoughts on the Ductules of the Aging Human Lacrimal Gland.- The Parenchyma Accompanying Major Extraglandular Ducts within the Rat Lacrimal Cord.- Protein Secretion and the Identification of Neurotransmitters in the Isolated Pig Lacrimal Gland.- Anti-Muscarinic Acetylcholine Receptor-Like Immunoreactivity in Lacrimal Glands.- Innervation and Mast Cells of the Rat Lacrimal Gland: The Effects of Age.- Immunogold Localization of Prolactin in Acinar Cells of Lacrimal Gland.- Lacrimal Gland: Electrophysiology, Water and Ion Transport.- Subcellular Organization of Ion Transporters in Lacrimal Acinar Cells: Seeretagogue-Induced Dynamics.- Effect of Acetylcholine on the Membrane Conductance of the Intralobular Duct Cells of the Rat Exorbital Lacrimal Gland.- The Circadian Rhythm of Lacrimal Secretion and Its Parameters, Determined in a Group of Healthy Individuals, and Its Potential Diagnostic and Therapeutic Significance.- Effects of Dihydrotestosterone and Prolactin on Lacrimal Gland Function.- A Na: H Exchanger Subtype Mediates Volume Regulation in Bovine Corneal Epithelial Cells.- Endocytosis and Exocytosis in Rabbit Lacrimal Gland Acinar Cells.- Lacrimal Gland: Signal Transduction and Protein Secretion.- The Inositol Phosphate-Calcium Signalling System in Lacrimal Gland Cells.- Characterization of Rat Lacrimal Gland Protein Kinase C: Effects of Phorbol Esters and PKC Inhibitors on Histone Kinase Activity and Labelled Protein Discharge.- Inhibition of Lacrimal Function by Selective Opiate Agonists.- Second Messenger Modulation of IgG Secretion from Chicken Lacrimal Gland.- Identification of Sigma Receptors in Lacrimocytes and Their Therapeutic Implication in Dry Eye Syndrome.- Role of Protein Kinase C in ?1-Adrenergic and Cholinergic Agonist Stimulated Protein Secretion.- The Role of Membrane Channels in IgG Secretion by Plasma Cells in the Chicken Lacrimal Gland.- Binding Characteristics, Immunocytochemical Location and Hormonal Regulation of Androgen Receptors in Lacrimal Tissue.- Lacrimal Gland: Immunology.- Regulation of Lacrimal Gland Immune Responses.- The Lacrimal Antibody Response to Viral and Chlamydial Infections.- Neural-Endocrine Control of Secretory Component Synthesis by Lacrimal Gland Acinar Cells: Specificity, Temporal Characteristics and Molecular Basis.- Lymphocyte Adhesive Interaction with Lacrimal Gland Acinar Epithelium Involves Carbohydrate Recognition.- Subclass Expression of IgA in Lacrimal Glands of Patients with Sjögren's Syndrome.- Influence of the Endocrine Environment on Herpes Virus Infection in Rat Lacrimal Gland Acinar Cells.- Sialodacryoadenitis Virus Infection of Rat Lacrimal Gland Acinar Cells.- Molecular Biological Approaches to the Study of the Lacrimal Gland and Tear Film.- Growth Factor and Receptor Messenger RNA Production in Human Lacrimal Gland Tissue.- Human Lacrimal Gland Secretes Proteins Belonging to the Group of Hydrophobic Molecule Transporters.- Transcription of Message for Tumor Necrosis Factor-Alpha by Lacrimal Gland is Regulated by Corneal Wounding.- Androgen Regulation of Secretory Component mRNA Levels in the Rat Lacrimal Gland.- Vasoactive Intestinal Peptide Induces Primary Response Gene Expression in Lacrimal Gland.- Tear Film Composition and Biophysical Properties.- Composition and Biophysical Properties of the Tear Film: Knowledge and Uncertainty.- Structure and Function of the Tear Film.- Ocular Surface Changes Induced by Repeated Impression Cytology.- Developmental Appearance of a Component of the Glycocalyx of the Ocular Surface Epithelium in the Rat.- Mixing of the Tear Film under the Eyelids.- Viscoelastic Properties of Human Tears and Polymer Solutions.- Effect of Age on Human Tear Film Evaporation in Normals.- Advances in Ocular Tribology.- Effect of Systemic Ingestion of Vitamin and Trace Element Dietary Supplements on the Stability of the Pre-Corneal Tear Film in Normal Subjects.- Patterns of Cytokeratin Expression in Impression Cytology Specimens from Normal Human Conjunctival Epithelium.- Increase in Tear Film Lipid Layer Thickness Following Treatment of Meibomian Gland Dysfunction.- Tear Proteins and Growth Factors.- Analysis and Function of the Human Tear Proteins.- Tear Protein Composition and the Effects of Stimulus.- Growth Factors in Human Tear Fluid and in Lacrimal Glands.- Re-Examination of the Origin of Human Tear LDH.- Tear Proteins and Enzymes in the Chimpanzee.- Comparisons of Tear Proteins in the Cow, Horse, Dog and Rabbit.- Tear Protein G Originates from Denatured Tear Specific Prealbumin as Revealed by Anti-TSP Antibody.- Tear Lactoferrin Levels and Ocular Bacterial Flora in HIV Positive Patients.- Vitronectin in Human Tears-Protection Against Closed Eye Induced Inflammatory Damage.- Mucopolysaccharide Degrading Enzymes (MPDE) in the Tear Fluid: A New Diagnostic Test for Rapid Detection of Acute Ocular Infections.- Tear Immunoglobulins and Lysozyme Levels in Corneal Ulcers.- Mucus and Pseudomonas aeruginosa Adherence to the Cornea.- Measurement of Human Tear Lysozyme Using a Novel Synthetic Substrate.- Retrospective Use of Frozen Schirmer Strips for the Measurement of Tear Lysozyme.- Rapid Measurement of Selected Tear Proteins in Health and Disease Using the Touch Tear Microassay System.- Tear Film: Pharmacological Approaches and Effects.- The Tear Film: Pharmacological Approaches and Effects.- Influence of Various Pharmaceutical Agents on Tear Flow as Assessed by Fluorophotometry.- Neural Stimulation of Conjunctival Goblet Cell Mucous Secretion in Rats.- Bioavailability of Prednisolone in Rabbits: Comparison of a High-Viscosity Gel and an Aqueous SuspensionSingle- and Repeated Applications.- Tear Film and Contact Lens Interactions.- Tear FilmContact Lens Interactions.- Electrophoretic Patterns of Human Denatured Tear Proteins and Glycoproteins from Normal Subjects and Soft Contact Lens Wearers.- The Refractive Index of Tears in Normals and Soft Lens Wearers.- The Role of Tear Deposits on Hydrogel Contact Lenses Induced Bacterial Keratitis: Pseudomonas aeruginosa Abhesives.- The Closed-Eye Challenge.- Artificial Tears.- Dry Eye Therapy: Evaluation of Current Directions and Clinical Trials.- Artificial Tear Issues.- Evaluation of Effects of a Physiologic Artificial Tear on the Corneal Epithelial Barrier: Electrical Resistance and Carboxyfluorescein Permeability.- Evaluation of a Physiological Tear Substitute in Patients with Keratoconjunctivitis Sicca.- A Scanning Electron Micrographic Comparison of the Effects of Two Preservative-Free Artificial Tear Solutions on the Corneal Epithelium as Compared to a Phosphate Buffered Saline and a 0.02% Benzalkonium Chloride Control.- A Unique Therapeutic Artificial Tear Formulation.- Dry Eye Syndromes: Pathogenesis and Diagnosis.- Non-Sjögren Dry Eye: Pathogenesis, Diagnosis and Animal Models.- Abnormalities of the Structure of the Superficial Lipid Layer on the In Vivo Dry-Eye Tear Film.- Tear Osmolarity a New Gold Standard?.- Micropachometric Differentiation of Dry Eye Syndromes.- Decreased Tear Secretion in Chernobyl Children: External Eye Disorders in Children Subjected to Long-Term Low-Dose Radiation.- Lacrimal Dysfunction in Pediatric Acquired Immunodeficiency Syndrome.- Keratoconjunctivitis Sicca in HIV-1 Infected Female Patients.- The Increase of the Blink Interval in Ophthalmic Procedures.- Changes in Tear Ion Concentrations in Dry-Eye Disorders.- Quantitative Cellular Evaluation of Conjunctival Squamous Metaplasia in the Dry Eye Patient.- Topical Anesthetic Induced Pain as a Diagnostic Tool for Keratoconjunctivitis Sicca (KCS).- Lacrimation Kinetics as Determined by a Schirmer-Type Technique.- A Precise Method of Using Rose Bengal in the Evaluation of Dry Eye and the Detection of Changes in Its Severity.- Dry Eye Syndromes: Treatment and Clinical Trials.- Dry Eye Syndromes: Treatment and Clinical Trials.- Keratoprosthesis in End-Stage Dry Eye.- Amylase in Mare Lacrimale in Patients with Submandibular Salivary Gland Transplantation to the Lacrimal Basin.- A Subjective Approach to the Treatment of Dry Eye Syndrome.- Simulation of Lacrimal Gland Output: a Tear Jet for Replacing Eye Moisture in Sjögren's Syndrome.- Characteristics of a Canine Model of KCS: Effective Treatment with Topical Cyclosporine.- Treatment of Severe Eye Dryness and Problematic Eye Lesions with Enriched Bovine Colostrum Lactoserum.- The Efficiency of Short-Wave Diathermy and Laser Stimulation of the Lacrimal Gland in the Treatment of Dry Eye Syndrome.- Effect of Collagen Punctal Occlusion on Tear Stability and Volume.- Sjögren's Syndrome: Pathogenesis and Diagnosis.- Sjögren's Syndrome: Immunologic and Neuroendocrine Mechanisms.- Murine Models of Sjögren's Syndrome.- Utilization of the Non-Obese Diabetic (NOD) Mouse as an Animal Model for the Study of Secondary Sjögren's Syndrome.- Expression of Granzyme A and Perforin in Lacrimal Gland of Sjögren's Syndrome.- Epstein-Barr Virus and the Lacrimal Gland Pathology of Sjögren's Syndrome.- Sjögren's Syndrome (SS) and Epstein-Barr Virus (EBV) Reactivation.- Hypothesis for Autoantigen Presentation and T Cell Activation.- Gingival Impression: A New Biological Test for Xerostomia in Diagnosis of Sjögren's Syndrome.- Sjögren's Syndrome Diagnosis: A Comparison of Conjunctival and Gingival Impressions and Salivary Gland Biopsy.- Correlation of Labial Salivary Gland Biopsies with Ocular and Oral Findings in Patients with Sjögren's Syndrome.- A Comparative Study Between Tear Protein Electrophoresis and Accessory Salivary Gland Biopsy in Sjögren's Syndrome.- Sjögren's Syndrome: Treatment.- Sjögren's SyndromeClose to Cause and Cure?.- Androgen-induced suppression of autoimmune disease in lacrimal glands of mouse models of Sjögren's syndrome.- Effect of Sodium Sucrose-Sulfate on the Ocular Surface of Patients with Keratoconjunctivitis Sicca in Sjögren's Syndrome.- Comparative Efficacy of Androgen Analogues in Suppressing Lacrimal Gland Inflammation in a Mouse Model (MRL/lpr) of Sjögren's Syndrome.- Sjögren's Syndrome Associations.- National Sjögren's Syndrome Association.- Sjögren's Syndrome Foundation Inc..- Advertisement: Lacrimedics, Inc..- Contributors.


Titel: Lacrimal Gland, Tear Film, and Dry Eye Syndromes
Untertitel: Basic Science and Clinical Relevance
EAN: 9780306446764
ISBN: 0306446766
Format: Fester Einband
Herausgeber: Springer US
Genre: Medizin
Anzahl Seiten: 756
Gewicht: 1285g
Größe: H241mm x B160mm x T45mm
Jahr: 1994
Auflage: 1994

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