MHC Ligands and Peptide Motifs

This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.

Inhalt

1. History and Overview.- 2. The MHC Genes.- 3. The Structure.- 4. The Function.- 5. Recognition by Immune Cells.- Appendix A: Useful Internet Addresses.- Appendix B: Computer Programs.- Appendix C: Abbreviations.