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Injury Models of the Central Nervous System

  • Fester Einband
  • 743 Seiten
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This volume discusses experimental brain injury models that contain valuable information carefully chosen to widen the researchers' horizon about neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have been adapted and made ready for application in laboratory settings. For easier navigation, the chapters are categorized into 6 parts: Introduction, General Consideration in Using Animal Laboratory in CNS Injury Research, Classical TBI Models and Their Link with Pathophysiological Features of CBS Injury Models, Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, Outcome Measures in Brain Injury Models, and Future Directions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards the progress of this discipline.

Includes cutting-edge methods and protocols

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from experts

Includes supplementary material:

Part I Introduction 1. The History and Evolution of Experimental Traumatic Brain Injury ModelsJohn PovlishockPart II. General Consideration in Using Animal Laboratory in CNS Injury Research2. Clinical Traumatic Brain Injury in the Preclinical SettingJustin Berkner, Rebekah Mannix, and Jianhua Qiu3. Rodent Models of Traumatic Brain Injury: Methods and ChallengesNiklas Marklund4. Traumatic Brain Injury Models in AnimalsElham Rostami5. Systematic Review of Traumatic Brain Injury Animal ModelsHelen W. Phipps6. Methods of Drug Delivery in NeurotraumaYing Deng-Bryant, Ryan Readnower, Lai Yee Leung, Frank Tortella, and Deborah Shear7. Bridging the Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental TestingPamela J. VandeVord, Alessandra Dal Cengio Leonardi, and David Ritzel8. Cellular Mechanisms and Behavioral Outcomes in Blast-Induced Neurotrauma: Comparing Experimental Set-UpsZachary S. Bailey, William Brad Hubbard, and Pamela J. VandeVord9. Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics for Traumatic Brain InjuryZaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou Abbass, and Firas Kobeissy10. Role of Systems Biology in Brain Injury Biomarker Discovery: A Neuroproteomic ApplicationZaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou Abbass, Hiba Ghandour, Stefania Mondello, and Firas KobeissyPart III Classical TBI Models and Their Link with Pathophysiological Features of CNS Injury Models11. The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and ProtocolNicole Osier and C. Edward Dixon12. Weight Drop Models in Traumatic Brain InjuryBrian T. Kalish and Michael J. Whalen13. Midline (Central) Fluid Percussion Model of Traumatic Brain InjuryRachel K. Rowe, Daniel R. Griffiths, and Jonathan Lifshitz14. Lateral (Parasagittal) Fluid Percussion Model of Brain InjuryKen C. Van and Bruce G. Lyeth15. Impact Acceleration Model of Diffuse Traumatic Brain InjurySarah C. Hellewell, Jenna M. Ziebell, Jonathan Lifshitz, and M. Cristina Morganti-Kossmann16. Experimental Models for Neurotrauma ResearchJohan Davidsson and Mårten Risling<17. A Porcine Model of Traumatic Brain Injury via Head Rotational AccelerationD. Kacy Cullen, James P. Harris, Kevin D. Browne, John A. Wolf, John E. Duda, David F. Meaney, Susan S. Margulies, and Douglas H. Smith18. Pediatric Rodent Models of Traumatic Brain InjuryBridgette D. Semple, Jaclyn Carlson, and Linda J. Noble-Haeusslein19. Modeling Pediatric Brain Trauma: Piglet Model of Controlled Cortical ImpactJennifer C. Munoz Paraja, Kristen Keeley, Ann-Christine Duhaime, and Carter P. Dodge20. Thromboembolic Model of Cerebral Ischemia and Reperfusion in MiceAli Alawieh, Wenxue Wang, Aarti Narang, and Stephen Tomlinson21. Animal Stroke Model: Ischemia/Reperfusion and Intracerebral HemorrhageChanghong Ren, Christopher Sy, Jinhuan Gao, Yuchuan Ding, and Xunming Jiiv ="" special="" topics="" in="" cns="" trauma:="" comorbid="" conditions="" injury22. Combined Neurotrauma Models: Experimental Models Combining Traumatic Brain Injury and Secondary InsultsDennis W. Simon, Vincent M. Vagni, Patrick M. Kochanek, and Robert S. B. Clark23. Microdialysis as Clinical Evaluation of Therapeutic Hypothermia in Rat Subdural Hematoma ModelShoji Yokobori, Markus S. Spurlock, Stephanie W. Lee, Shyam Gajavelli, and Ross M. Bullock24. Repetitive Transcranial Magnetic Stimulation as a Novel Therapy in Animal Models of Traumatic Brain InjuryThangavelu Soundara Rajan, Salvatore Cuzzocrea, Daniele Bruschetta, and Angelo Quartarone25. Experimental Models Combining TBI, Hemorrhagic Shock, and HypoxemiaLai Yee Leung, Ying Deng-Bryant, Deborah Shear, and Frank Tortella26. Experimental Models Combining Traumatic Brain Injury and HypoxiaEric P. Thelin27. Animal Models of Post-Traumatic Seizures and EpilepsyAlexander V. Glushakov, Olena Y. Glushakova, Sylvain Doré, Paul R. Carney, and Ronald L. Hayes28. Closed-Head TBI Model of Multiple-MorbidityFloyd J. Thompson, Jiamei Hou, and Prodip K. BosePart V Outcome Measures in Brain Injury Models29. Cognitive Evaluation Using Morris Water Maze in NeurotraumaYing Deng-Bryant, Lai Yee Leung, Krista Caudle, Frank Tortella, and Deborah Shear30. Assessment of Cognitive Function in the Water Maze Task: Maximizing Data Collection and Analysis in Animal Models of Brain InjuryMark D. Whiting and Olga N. Kokiko-Cochran31. Detecting Behavioral Deficits Post Traumatic Brain Injury in RatsHibah O. Awwad32. Advanced and High Throughput Method for Mitochondrial Bioenergetics Evaluation in NeurotraumaJignesh D. Pandya, Patrick G. Sullivan, Lai Yee Leung, Frank C. Tortella, Deborah A. Shear, and Ying Deng-Bryant33. Determination of Vascular Reactivity of Middle Cerebral Arteries from Stroke and Spinal Cord Injury Animal Models Using Pressure MyographyMohammad A. Anwar and Ali H. Eid34. Assessment of Basilar Artery Reactivity in Stroke and Subarachnoid Hemorrhage Using Wire MyographCrystal M. Ghantous, Zeina Azrak, Farah Abdel Rahman, Hana A. Itani, and Asad Zeidan35. Magnetic Resonance Imaging in Experimental Traumatic Brain InjuryQiang Shen, Lora Tally Watts, Wei Li, and Timothy Q. Duong36. A Simplified Workflow for Protein Quantitation of Rat Brain Tissues Using Label-Free Proteomics and Spectral CountingAngela M. Boutté, Shonnette F. Grant, and Jitendra R. Dave37. Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain InjuryHassan Al-Ali, Vance P. Lemmon, and John L. Bixby38. Postnatal Neural Stem Cells in Treating Traumatic Brain InjuryHussein Gazalah, Sarah Mantash, Naify Ramadan, Sawsan Al Lafi, Sally El Sitt, Hala Darwish, Hassan Azari, Lama Fawaz, Noël Ghanem, Kazem Zibara, Rose-Mary Boustany, Firas Kobeissy, and Jihane Soueid39. A Novel Biopsy Method for Isolating Neural Stem Cells from the Subventricular Zone of the Adult Rat Brain for Autologous Transplantation in CNS InjuriesHadi Aligholi, Gholamreza Hassanzadeh, Ali Gorji, and Hassan AzariPart VI Future Directions40. Challenging the Paradigms of Experimental TBI Models: From Preclinical to Clinical PracticeFrank Tortella


Titel: Injury Models of the Central Nervous System
Untertitel: Methods and Protocols
EAN: 9781493938148
ISBN: 978-1-4939-3814-8
Format: Fester Einband
Herausgeber: Springer, Berlin
Genre: Medizin
Anzahl Seiten: 743
Gewicht: 1658g
Größe: H49mm x B260mm x T185mm
Jahr: 2016
Untertitel: Englisch
Auflage: 1st ed. 2016

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