Immunotoxicity Testing

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This text explores recent critical advances in immunotoxicology. It provides current, lab-ready procedures along with the correspo...

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This text explores recent critical advances in immunotoxicology. It provides current, lab-ready procedures along with the corresponding background information necessary to identify effective testing approaches for chemicals and drugs.
Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls. Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology.
Features step-wise protocols for assays used in immunotoxicity safety evaluation Provides helpful hints to overcome assay problems or increased assay variability Includes chapters covering both clinical evaluation and alternative approaches Offers discussions of new assays likely to impact future testing protocols Presents discussions of age and gender considerations in immune safety testing Incorporates testing approaches designed to address emerging immune health risk concerns Includes supplementary material: sn.pub/extras
Inhalt
Immunotoxicity Testing: Methods and Protocols Editor Rodney R. Dietert Table of Contents: Table of Contents Preface Contributors Part I - Introduction Immunotoxicology Testing: Past and Future Michael I. Luster and G. Frank Gerberick Part II - Overview and Health-Risk Considerations Developmental Immunotoxicity (DIT): The Why, When and How of DIT Testing. Rodney R. Dietert and Jamie DeWitt An In Vivo Approach to Test Immunosensitization by Low Moelcular Weight Compounds Irene S. Ludwig, Lydia M. Kwast, Daniëlle Fiechter, Raymond H.H. Pieters Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing Rodney R. Dietert, Janice M. Dietert and Jerrie Gavalchin Markers of Inflammation Dori R. Germolec, Rachel P. Frawley, and Ellen Evans Evaluating Macrophages in Immunotoxicity Testing John B. Barnett and Kathleen M. Brundage Part III Immunotoxicity and Host Resistance Models Host Resistance Assays Including Bacterial Challenge Florence G. Burleson and Gary R. Burleson Viral Host Resistance Studies Wendy Jo Freebern Parasite Challenge as Host Resistance Models for Immunotoxicity Testing Robert W. Luebke Tumor Challenges in Immunotoxicity Testing Sheung Ng, Kotaro Yoshida, and Judith T. Zelikoff Part IV Testing Protocols inRodents and Other Laboratory Animals The T-dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents Lisa M. Plitnick and Danuta J. Herzyk The T-Dependent Antibody Response to Sheep Erythrocytes Kimber L. White, Jr., Deborah L. Musgrove, and Ronnetta D. Brown 13. The Delayed Hypersensitivity (DTH) Assay Using Protein and Xenogeneic Cell Antigens Rodney R. Dietert, Terry L. Bunn and Ji-Eun Lee 14. The Cytotoxic T Lymphocyte (CTL) Assay For Evaluating Cell-Mediated Immune Function Gary R. Burleson, Florence G. Burleson and Rodney R. Dietert 15. NK Cell Assays in Immunotoxicity Testing Qing Li 16. The Local Lymph Node Assay and Skin Sensitization Test Ian Kimber and Rebecca J. Dearman 17. Use of Contact Hypersensitivity in Immunotoxicity Testing Jacques Descotes 18. Evaluation of Apoptosis in Immunotoxicity Testing Sadiye Amcaoglu Rieder, Dilip Vakharia, Prakash S. Nagarkatti and Mitzi Nagarkatti 19. Dendritic Cells in Immunotoxicity Testing Donghong Gao and David A. Lawrence 20. Evaluating Cytokines in Immunotoxicity Testing Emanuela Corsini an