Mechanisms of DNA Damage Recognition in Mammalian Cells

Inhalt

1. Medical Background: Human DNA Damage Recognition and Processing Disorders.- 2. Animal Models of DNA Damage Recognition and Processing Disorders.- 3. DNA Structure: Inherent Instability and Genotoxic Reactions.- 4. Molecular Recognition Strategies I: One Enzyme-One Substrate Motifs.- 5. Molecular Recognition Strategies II: (A)BC Excinuclease.- 6. Mammalian Nucleotide Excision Repair.- 7. Molecular Determinants of Damage Recognition by Mammalian Nucleotide Excision Repair.- 8. Molecular Crosstalks at Carcinogen-DNA Adducts.- 9. Intragenomic Hierarchies of DNA Damage Recognition.- 10. Recognition of DNA Damage During Replication.- 11. DNA Damage Recognition: Toxicological and Medical Prospects.