Ferroptosis: Mechanism and Diseases

This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis.

While covering basic concepts, the book delvesinto mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.

Provides a unique perspective on practical aspects of ferroptosis, with in-depth coverage of pathologies from Cancer to COVID-19 Gives a comprehensive and up-to-date guide of small molecules modulating ferroptosis and their potential mechanism of action Discusses other non-apoptotic forms of cell death and the role of ferritinophagy in ferroptosis

Autorentext

Dr. Andrés F. Flórez is currently a Postdoctoral Fellow in the Department of Molecular and Cellular Biology (MCB) at Harvard University. His research is focused in understanding the oncogene-based mechanisms regulating ferroptosis and to use this knowledge for designing new therapeutic strategies. He is also interested in the role of ferroptosis in controlling bacterial cell populations.

Dr. Hamed Alborzinia is a Postdoctoral Fellow in the Division of Stem Cells and Cancer at the German Cancer Research Center (DKFZ). He also belongs to the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in Heidelberg, Germany. His main research focus is to understand the metabolic properties of cancer cells in connection to novel forms of cell death, including ferroptosis.

Inhalt
Foreword.- Ferroptosis: Concepts and Definitions.- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors.- Iron Homeostasis and Metabolism: Two Sides of a Coin.- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis.- Emerging Role for Ferroptosis in Infectious Diseases.- Small Molecule Regulators of Ferroptosis.- Necroptosis, The other main Caspase-Independent Cell Death.