Etiology of Hodgkin s Disease

This volume reports the proceedings of a NATO Advanced Workshop held at Cameron House Hotel, Loch Lomond, Scotland, from May 2 - 5, 1994. The major impetus for this workshop was the realisation, over the past 7 years, that the Epstein-Barr virus is associated with a proportion of cases of Hodgkin's disease and is likely to play an aetiological role. There were four main aims of the workshop: first, to discuss the recent findings in relation to Epstein Barr virus and the aetiology of Hodgkin's disease; second, to relate these data to the epidemiology of Hodgkin's disease; third, to discuss other potential aetiological factors and finally, to discuss future directions for research into Hodgkin's disease. Leading experts in the field have contributed chapters to this volume. There is some overlap among chapters, particularly regarding Epstein-Barr virus, thereby allowing different groups to express views on similar topics. Perhaps, however, the most surprising feature of the workshop was the lack of controversy regarding the role of Epstein-Barr virus in Hodgkin's disease, an association that was treated with great scepticism at the beginning of the decade. The first three chapters, by Alexander, Taylor et al., and Levine el al., discuss the epidemiology of Hodgkin's disease with particular attention to clustering and genetic susceptibility. These chapters represent the first attempt to bring together epidemiological and molecular studies in Hodgkin's disease.

Klappentext

Proceedings of a NATO ARW held in Loch Lomond, Scotland, May 2-5, 1994.

Zusammenfassung
Proceedings of a NATO ARW held in Loch Lomond, Scotland, May 2-5, 1994.

Inhalt
Epidemiology: Overview and spatial clustering.- Evidence of an increased frequency of HLA-DPB1 *0301 in Hodgkin's disease supports an infectious aetiology.- What can we learn about the aetiology of Hodgkin's disease from family studies.- Epstein-Barr virus and lymphomas: An overview.- Hodgkin's disease and Epstein-Barr virus.- Relationship between expression of cellular genes and Epstein-Barr virus in Hodgkin's disease.- The epidemiology of EBV-associated Hodgkin's disease.- Hodgkin's disease in human immunodeficiency virus infected individuals.- Hodgkin's disease and human herpesvirus-6: A model for studies of new aetiological agents.- The Reed-Sternberg cell and the CD30 antigen.- CD30 ligand: Cloning, characterisation and biological activities.- Single cell PCR at the DNA and RNA level: A novel approach to the study of Hodgkin's disease.- The nature of the lymphocytes in Hodgkin's disease.- Propagation of Hodgkin and Reed-Sternberg cells.- A SCID mouse model of Hodgkin's disease? Transplantation of Hodgkin's and non-Hodgkin's lymphomas into severe combined immunodeficient mice.- The pathogenesis of Hodgkin's disease: Oncogene, tumour suppressor gene, and Epstein-Barr viral studies.- Tumour suppressor genes in Hodgkin's disease.