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68Ga-DOTATOC/DOTANOC: synthesis and dosimetry

  • Kartonierter Einband
  • 92 Seiten
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Radiolabeled peptides are of increasing interest in nuclear oncology. In recent years, special emphasis has been given to the deve... Weiterlesen
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Beschreibung

Radiolabeled peptides are of increasing interest in nuclear oncology. In recent years, special emphasis has been given to the development of peptides labeled with positron emitters. Among these, 68Ga deserves special attention as an alternative to FDG, because it is available from an inhouse generator rendering 68Ga radiopharmacy independent of an onsite cyclotron. 68Ga has a half-life of 68 min and decays by 89% through positron emission. The parent, 68Ge, is accelerator produced and decays with a half-life of 270.8 days by electron capture. Several bifunctional chelators based on 1,4,7- triazacyclononane-N,N',N''-triacetic acid and 1,4,7,10- tetraazacyclododecane-N,N',N'',N'''- tetraacetic acid (DOTA) macrocycles are available for coupling to peptides and other biomolecules. Clinical studies were performed with 68Ga-DOTA, Tyr3- octreotide, localizing neuroendocrine tumors with higher sensitivity than 111In- diethylenetriaminepentaacetic acid-octreotide. In this study 68Ga-DOTANOC/DOTATOC was prepared using inhouse 68Ge/68Ga generator and radiation exposure was measured to nuclear medicine staff during handling the generator.

Autorentext

Durgesh Kumar Dwivedi a Physicist & a RSO. Masters from the Dept of Nuclear Medicine at AIIMS, New Delhi, INDIA and presently, research scholar in the Dept of NMR & MRI Facility, AIIMS. Currently, trying to develop some of novel techniques for the diagnosis of prostate cancer (using MRI/MRSI/PET/DWI etc).

Produktinformationen

Titel: 68Ga-DOTATOC/DOTANOC: synthesis and dosimetry
Untertitel: PREPARATION OF 68Ga-DOTA-TOC/-NOC FROM 68Ge/68Ga GENERATOR AND THE RADIATION EXPOSURE TO NUCLEAR MEDICINE STAFF DURING HANDLING 68Ge/68Ga GENERATOR
Autor:
EAN: 9783844310962
ISBN: 978-3-8443-1096-2
Format: Kartonierter Einband
Herausgeber: LAP Lambert Academic Publishing
Genre: Medizin
Anzahl Seiten: 92
Gewicht: 156g
Größe: H5mm x B220mm x T150mm
Jahr: 2011