Developmental Neuropathology of Schizophrenia

This volume reports the proceedings of a NATO Advanced Workshop held in Castelvecchio Pas coli, Italy, from August 28 - September 1, 1989. An important inspiration for this Workshop came from our studies in Helsinki and Denmark, which have found that exposure to an influenza epidemic during the second trimester of fetal development increases the risk of adult schizophrenia. This finding has stimulated an important new hypothesis in the study of the etiology of schizophrenia. It has suggested the possiblity that disturbances of brain development during gestation may contribute to the risk of adult schizophrenia. We determined that it would be of value to bring together schizophrenia researchers and those doing basic studies of the development of the brain. Both groups of researchers were encouraged to communicate at a level that would help other scientists to integrate their knowledge and techniques into their own discipline. For this reason, perhaps, the papers of this volume are remarkably clear and not difficult to understand. The first four chapters describe the neurochemical and structural aspects of brain development. The chapter by Dziegielewska and Saunders discusses transport mechanisms and the properties of endogenous and exogenous substances that control the internal environment of the developing brain. In the second chapter, Nowakowski reports on his studies of the develop ment of the hippocampus in mice genetically inbred to exhibit disruptions of neural migration.

Klappentext

Proceedings of a NATO ARW held in Castelvecchio Pascoli, Italy, August 28-September 1, 1989

Zusammenfassung
Proceedings of a NATO ARW held in Castelvecchio Pascoli, Italy, August 28-September 1, 1989

Inhalt
The Developing Brain.- The Internal Environment of the Developing Brain.- Neuronal Migration and Differentiation During Normal and Genetically Perturbed Development of the Hippocampal Formation.- Neurochemical Aspects of the Developing Brain.- Is the Differential Localization of Specific Plasma Proteins in the Developing Neo- and Archicortex a Reflection of Differences in Trans-Barrier Transport? Possible Implications for the Neuropathology of Schizophrenia.- Dopaminergic Innervation of the Cerebral Cortex: Developmental and Organizational Differences in Primates as Compared to Rodents.- Neuropathological Indicants of Neurodevelopmental Anomalies in Schizophrenics.- Clinical and Neurodevelopmental Aspects of Brain Pathology in Schizophrenia.- Perinatal Complications in Schizophrenics.- Obstetrical Events and Adult Schizophrenia.- Structural Imaging and Neuropsychological Evidence of Neurodevelopmental Anomalies.- Structural Brain Measurements on MRI Scans in Schizophrenia: Evidence of Neurodevelopmental Pathology.- The Possible Neurodevelopmental Significance of Structural Imaging Findings in Schizophrenia.- Morphologic Markers of Neurodevelopmental Paths to Schizophrenia.- Facts about Schizophrenia and Neurodevelopment.- Neurodevelopment and the Chronological Curiosities of Schizophrenia.- A Neurodevelopmental Approach to Schizophrenia Research.- Participants.- Author Index.