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Copper Transport and Its Disorders

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  • 284 Seiten
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Proceedings of a satellite meeting of the European Human Genetic Society held in Sestri Levante, Italy, May 21-25, 1997This book i... Weiterlesen
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Proceedings of a satellite meeting of the European Human Genetic Society held in Sestri Levante, Italy, May 21-25, 1997

This book is a compilation of presentations at the first meeting devoted to the mo lecular and cellular biology of copper transport. When we first considered the possible program for the meeting, we felt that a forum to integrate the recent advances in molecular understanding of copper transport with the older knowledge of copper metabolism was needed. In addition we wished to have a strong emphasis on the diseases of copper includ ing the genetic diseases, Menkes and Wilson, and other possible health aspects of this met al seen from a molecular perspective. Overall we were very happy with the success of the meeting, and most participants were very enthusiastic. Unfortunately we were not able to obtain manuscripts from every contributor, but the selection in this book covers most of the topics discussed. The history of biological research into copper dates from the latter half of the last century when the presence of copper as a component of living systems was first noted, but it was not until the 1920s that the essential role of copper was first recognized. l. S. McHargue found that plants and animals needed copper for optimal growth and health and proposed that copper was needed for life (McHargue, 1925). Other groups soon confirmed these observations in plants. In animals the requirement of copper for hematopoiesis was discovered in 1928 (Hart et aI.


Introductory Chapter; J.F.B. Mercer, A. Leone. Copper Transport in Mammals; M.C. Linder, et al. Models to Evaluate Health Risks Derived from Copper Exposure/Intake in Humans; M. Olivares, et al. Cu Metabolism in the Liver; H.J. McArdle, et al. Multiple Forms of the Menkes Cu-ATPase; E.D. Harris, et al. The Cell Biology of the Menkes Disease Protein; M.J. Petris, et al. Functional Analysis of the Menkes Protein (MNK) Expressed from a cDNA Construct; S. La Fontaine, et al. Mutation Spectrum of ATP7A the Gene Defective in Menkes Disease; Z. Tümer, et al. Animal Models of Menkes Disease; J.F.B. Mercer, et al. Developmental Expression of the Mouse Mottled and Toxic Milk Genes; Y.-M. Kuo, et al. The Treatment of Wilsons Disease; G.J. Brewer. Indian Childhood Cirrhosis and Tyrolean Childhood Cirrhosis: Disorders of a Copper Transport Gene? M.S. Tanner. Animal Models of Wilsons Disease; J.McC. Howell. Copper-Binding Properties of the N-Terminus of the Menkes Protein; P. Cobine, et al. Expression, Purification, and Metal Binding Characteristics of the Putative Copper Binding Domain from the Wilson Disease Copper Transporting ATPase (ATP7B); M. DiDonato, et al. 9 additional chapters. Index.


Titel: Copper Transport and Its Disorders
Untertitel: Molecular and Cellular Aspects
EAN: 9780306460456
ISBN: 0306460459
Format: Fester Einband
Herausgeber: Springer US
Anzahl Seiten: 284
Gewicht: 594g
Größe: H241mm x B160mm x T20mm
Jahr: 1999
Auflage: 1999

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