Clinical Applications of Mass Spectrometry

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As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Protocols, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical protocols, and detailed notes on troubleshooting and avoiding known pitfalls. Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Protocols offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.
Covers a range of gas chromatography- and liquid chromatography-based mass spectrometry techniques and systems Includes multiple analytical options presented for many analytes Serves as a comprehensive resource of mass spectrometry procedures for the clinical laboratory whether new to MS or experienced Contains well-organized procedures that will greatly facilitate assay implementations Provides a resource for materials and hints for troubleshooting problems Covers a wide range of analytes including hormones, drugs, and metabolites Includes supplementary material: sn.pub/extras
Inhalt
1. The Evolution of Mass Spectrometry in the Clinical Laboratory Catherine A. Hammett-Stabler and Uttam Garg 2. Measurement of Plasma/Serum Acylcarnitines Using Tandem Mass Spectrometry Nathalie Lepage and Susan Aucoin 3. Comprehensive Determination of Amino Acids for Diagnosis of Inborn Errors of Metabolism Dennis J. Dietzen and Annette L. Weindel 4. Identification and Quantitation of Amphetamine, Methamphetamine, MDMA, Pseudoephedrine, and Ephedrine in Blood, Plasma, and Serum Using Gas Chromatography-Mass Spectrometry (GC/MS) Josh Gunn, Scott Kriger, and Andrea R. Terrell 5. Quantification of Antidepressants Using Gas Chromatography-Mass Spectrometry Ruth E. Winecker 6. Quantitation of Argatroban in Plasma using Liquid Chromatography Electrospray Tandem Mass Spectrometry (UPLC-ESI-MS/MS) Ross J. Molinaro 7. Quantitation of Amobarbital, Butalbital, Pentobarbital, Phenobarbital, and Secobarbital in Urine, Serum, and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) Leonard L. Johnson and Uttam Garg 8. Quantitation of Benzodiazepines in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 9. LC-MS/MS Analysis of 13 Benzodiazepines and Metabolites in Urine, Serum, Plasma, and Meconium Stephanie J. Marin and Gwendolyn A. McMillin 10. Simultaneous Determination and Quantification of 12 Benzodiazepines in Serum or Whole Blood Using UPLC/MS/MS Josh Gunn, Scott Kriger, and Andrea R. Terrell 11. Determination of Benzoic Acid in Serum or Plasma by Gas Chromatography-Mass Spectrometry (GC/MS) Jeff M. Knoblauch, David K. Scott, Laurie D. Smith, and Uttam Garg 12. Quantification of Busulfan in Plasma Uing Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Marion L. Snyder and James C. Ritchie 13. Quantitation of Total 11-Nor-9-Carboxy-Delta 9-Tetrahydrocannabinol in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) C. Clinton Frazee III, Michael Kiscoan, and Uttam Garg 14. Quantitation of Cocaine, Benzoylecgonine, Ecgonine Methyl Ester, and Cocaethylene in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Steven W. Fleming, Amitava Dasgupta, and Uttam Garg 15. Identification and Quantitation of Cocaine, Benzoylecgonine, and Cocaethylene in Blood, Serum, and Plasma Using Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry (UPLC-MS/MS) Scott Kriger, Josh Gunn, and Andrea R. Terrell 16. Detection and Quantification of Cocaine and Benzoylecgonine in Meconium Using Solid Phase Extraction and UPLC/MS/MS Josh Gunn, Scott Kriger, and Andrea R. Terrell 17. Diagnosis of Creatine Metabolism Disorders by Determining Creatine and Guanidinoacetate in Plasma and Urine Qin Sun and William E. O'Brien 18. Broad Spectrum Drug Screening Using Electron-Ionization Gas Chromatography-Mass Spectrometry (EI-GCMS) Judy Stone 19. Broad Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry Judy Stone 20. High Sensitivity Measurement of Estrone and Estradiol in Serum and Plasma Using LC-MS/MS Mark M. Kushnir, Alan L. Rockwood, Bingfang Yue, and A. Wayne Meikle 21. 3-Hydroxy-Fatty Acid Analysis by Gas Chromatography-Mass Spectrometry Patricia M. Jones and Michael J. Bennett 22. Quantitation of Fentanyl in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 23. Determination of Total Homocysteine in Plasma Using Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC/MS/MS) Bruno Casetta 24. Quantitation of Homovanillic Acid (HVA) and Vanillylmandelic Acid (VMA) in Urine Using Gas Chromatography-Mass Spectrometry (GC/MS) Ryan Allenbrand and Uttam Garg 25. Quantitation of 17-OH-Progesterone (OHPG) for Diagnosis of Congenital Adrenal Hyperplasia (CAH) Ravinder J. Singh 26. Determination of Hydroxyurea in Serum or Plasma Using Gas Chromatography-Mass Spectrometry (GC/MS) David K. Scott, Kathleen Neville, and Uttam Garg 27. Quantitation of Ibuprofen in Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Gerry Huber and Uttam Garg 28. Quantitation of Indomethacin in Serum and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) Sarah Thomas, Amanda Sutton, and Uttam Garg 29. Quantitation of Iothalamate in Urine and Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Ross J. Molinaro and James C. Ritchie 30. Identification and Quantitation of Ketamine in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Megan Gamble, and Kim Cox 31. Measurement of Filter Paper Bloodspot Lead by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Denise M. Timko and Douglas F. Stickle 32. Multiplex Lysosomal Enzyme Activity Assay on Dried Blood Spots Using Tandem Mass Spectrometry X. Kate Zhang, Carole S. Elbin, Frantisek Turecek, Ronald Scott, Wei-Lien Chuang, Joan M. Keutzer, and Michael Gelb 33. Gas Chromatography-Mass Spectrometry Method for the Determination of Methadone and 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP) Christine L.H. Snozek, Matthew W. Bjergum, and Loralie J. Langman 34. Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) Method for Monitoring Methotrexate in the Setting of Carboxypeptidase-G2 Therapy Vikram S. Kumar, Terence Law, and Mark Kellogg 35. Quantitation of Methylmalonic Acid in Serum or Plasma Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry Jie Chen and Michael J. Bennett 36. Quantitation of Methylmalonic Acid in Plasma Using Liquid ChromatographyTandem Mass Spectrometry Claudine Fasching and Jasbir Singh 37. Monitoring of Mycophenolate Acid in Serum or Plasma Using LC Tandem Mass Spectrometry Catherine A. Hammett-Stabler, Diane Ciuffetti Geis, James Ritchie, and Christine Papadea 38. Quantitation of Nicotine, Its Metabolites, and Other Related Alkaloids in Urine, Serum, and Plasma Using LC-MS/MS Bingfang Yue, Mark M. Kushnir, Francis M. Urry, and Alan L. Rockwood 39. Quantitation of Opioids in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 40. Quantitation of Morphine, Codeine, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone, and 6-Monoacetylmorphine (6-MAM) in Urine, Blood, Serum, or Plasma Using Liquid Chromatography with Tandem Mass Spectrometry Detection Tim Dahn, Josh Gunn, Scott Kriger, and Andrea R. Terrell 41. Urine Organic Acid Analysis for Inherited Metabolic Disease Using Gas Chromatography-Mass Spectrometry Patricia M. Jones and Michael J. Bennett 42. Identification of Urine Organic Acids for the Detection of Inborn Errors of Metabolism Using Urease and Gas Chromatography-Mass Spectrometry (GC/MS) Stanley F. Lo, Velta Young, and William J. Rhead 43. Quantitation of Orotic Acid in Urine Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry Jie Chen and Michael J. Bennett 44. Quantitation of Oxycodone in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 45. Quantitation of Phencyclidine (PCP) in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Angela M. Ferguson and Uttam Garg 46. Quantitation of Sirolimus Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS) Magdalena Korecka and Leslie M. Shaw 47. Quantitation of Tacrolimus in Whole Blood Using High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC/MS/MS) Keri J. Donaldson and Leslie M. Shaw 48. Analysis of Testosterone in Serum Using Mass Spectrometry Robert L. Fitzgerald, Terrance L. Griffin, and David A. Herold 49. Determination of Tetrahydrozoline in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC/MS) Judy Peat and Uttam Garg 50. Quantitation of 25-OH-Vitamin D (25OHD) Using Liquid Tandem Mass Spectrometry (LC-MS/MS) Ravinder J. Singh 51. Identification and Quantitation of Zolpidem in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Lydia A. Harryman, and Melissa C. Norton 52. Identification and Quantitation of Zopiclone in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Melissa C. Norton, and Lydia A. Harryman