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Clinical Applications of Immunotoxins

  • Kartonierter Einband
  • 140 Seiten
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1 2 D. FITZGERALDI, I. PASTAN , and J. ROBERTUS Introduction . . . . . . . . . . . . . I 2 Toxin Structure-Function Properties 2 2... Weiterlesen
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Beschreibung

1 2 D. FITZGERALDI, I. PASTAN , and J. ROBERTUS Introduction . . . . . . . . . . . . . I 2 Toxin Structure-Function Properties 2 2. 1 Functions. . . . . . . . . . . . . . . . . . . . . . . . 2 2. 2 Binding. . . . . . . . . . . . . . . . . . . . . . . . . 3 3 Intracellular Processing - Cleavage and Reduction . . . . . . 4 3. 1 Cytosolic Activity . . . . . . . . . . . . . . . . 5 4 Immunotoxin Design and Testing. 6 5 Conclusion. . 8 References. . . . . 8 1 Introduction While various treatment approaches for cancer include reversal of the transformed phenotype, stimulation of immune responses, inhibition of metastatic spread and deprivation of key nutrients, the goal of immunotoxin treatment is the direct killing of malignant cells. Because they are enzymatic proteins that act catalytically to kill cells, bacterial and plant toxins are often employed as the cell-killing component of immunotoxins. Here we provide background information into the structure-func tion relationships of toxins and discuss how they can be combined with cell-binding antibodies or other ligands to generate immunotoxins. Bacterial and plant toxins (e. g. , diphtheria toxin, Pseudomonas exotoxin and ricin) are among the most toxic substances known. However, because they bind to cell surface receptors that are present on most normal cells, unmodified toxins are generally useless as anti-cancer agents. To convert toxins into more selective agents, their binding domains are either eliminated or disabled and replaceq with cell binding antibodies that are tumor-selective.

Klappentext

While over twenty clinical trials of targeted toxins have been conducted since 1980, a volume dedicated to a complete review of the efficacy, toxicity, and pharmacology of these agents in the clinical setting has not been published. This book fulfills the need for a reference source for review of previous results and methods of analogs for scientists designing these molecules and clinicians testing these agents on patients.



Inhalt

Introduction.- The Emerging Role of Ricin A-Chain Immunotoxins in Leukemia and Lymphoma.- Clinical Trials with Blocked Ricin Immunotoxins.- Saporin Immunotoxins.- Diphtheria Toxin Fusion Proteins.- Clinical Trials with Pseudomonas Exotoxin Immunotoxins.- Immunotoxins for Brain Tumor Therapy.- Conclusions.

Produktinformationen

Titel: Clinical Applications of Immunotoxins
Editor:
EAN: 9783642721557
ISBN: 3642721559
Format: Kartonierter Einband
Herausgeber: Springer Berlin Heidelberg
Genre: Medizin
Anzahl Seiten: 140
Gewicht: 224g
Größe: H235mm x B155mm x T7mm
Jahr: 2011
Auflage: Softcover reprint of the original 1st ed. 1998

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