Cellular and Molecular Toxicology of Nanoparticles

This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types.

Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called biomolecular corona.

The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.

A unique account of the effects on the transcriptome following exposure to nanoparticles A compilation of the latest findings to address the query on the potential mechanisms of nanoparticle induced cell death A highly timely edition for multidisciplinary readers to widen their knowledge on how nanomaterials interface with the biological environment

Autorentext

Dr. Quaiser Saquib is currently working as an Assistant Professor in Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia. He is also serving as coordinator of Al-Jeraisy Chair for DNA Research in KSU. He earned his PhD from AMU, India. Much of his experience has been doing the molecular toxicity and biophysical research. Dr. Saquib has been conferred "Scientist of the Year Award-2016" by National Environmental Science Academy, India and "Young Scientist Award 2008" by Environmental Mutagen Society of India. There are 46 research publications, 2 books and 2 book chapters has been added to his credentials. He is principal and co-investigator in several projects funded by National Plan for Science and Technology, Saudi Arabia. Dr. Saquib is also engaged in teaching and training of graduate and postgraduate students at KSU.

Dr. Mohammad Faisal is an Assistant Professor in the Department of Botany & Microbiology, King Saud University,Riyadh, Saudi Arabia. He received his PhD degree in Botany from the AMU, India. He is a well-known plant biotechnologist and an active researcher also worked as Postdoctoral Fellow at the Centro de Investigaciones Biologicas, Madrid, Spain and Young Scientist at AMU, Aligarh, India. He availed several national fellowships during his doctoral work. Dr. Faisal has been awarded Plant Biotechnologist Award-2017 by the SESR, India and Scientist of the Year Award-2015 by the NESA. He has published over 64 research articles and these papers have been cited over 1362 times with Google h index of 23. He holds life membership of several academic societies and fellow of the SESR. He is in the editorial board of the several peer-reviewed international journals.

Professor Abdulaziz A. Al-Khedhairy is currently serving as Director of Twasol Research Excellence Program in King Saud University, Riyadh, Saudi Arabia. He has been appointed at several key academic and administrative positions in KSU, including Dean of Community College, Assistant Vice-President for Graduate Studies and Research. Prof. Al-Khedhairy is also supervising Al-Jeraisy Chair for DNA Research. His research interest includes molecular genetics of inherited diseases in the Saudi community and interactions of eukaryotic DNA with genotoxic chemicals and their prolonged effect on human genes. He has published 160 research articles, 9 book chapters and 2 books. He also has one USA patient. He has been conferred with KACST Golden Award for Excellence in Research. As a PI and CO-I, he has successfully supervised several projects funded by KACST, KSA.

Dr. Abdulrahman Alatar is an Associate Professor at the Department of Botany & Microbiology, King Saud University, Riyadh, Saudi Arabia. He received his PhD degree in Plant Ecology in the year 2008 from KSU. He has been the Principal and Co-Investigator of the various projects funded by the different agencies and supervised 3 PhD students and7 MSc students. He holds membership of several academic societies and participated in several national and international conferences. He published more than 65 scientific articles in different international journals published by the Elsevier, Springer, Wiley, Taylor and Francis etc. His work has been cited in various leading journals. He is the recipient of several awards and honors and have various academic and administrative contributions in the KSU. Currently, he is also serving as the Vice Dean of Graduate Studies, KSU, Riyadh, Saudi Arabia.

Inhalt
Toxicity Assessment in The Nanoparticle Era.- Mechanisms of Uptake and Translocation of Nanomaterials in the Lung.- Transmucosal Nanoparticles: Toxicological Overview.- The Toxicity of Nanoparticles to Human Endothelial Cells.- The Role of Autophagy in Nanoparticles-Induced Toxicity and its Related Cellular and Molecular Mechanisms.- Nanoparticles-Caused Oxidative Imbalance.- Toxicity of Metal Oxide Nanoparticles.- Relevance of Physicochemical Characterization of Nanomaterials for Understanding Nano-Cellular Interactions.- Toxicogenomics: A New Paradigm for Nanotoxicity Evaluation.- Nickel Oxide Nanoparticles Induced Transcriptomic Alterations in HepG2 Cells.- Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona.- Cellular and Molecular Toxicity of Iron Oxide Nanoparticles.- Detection of DNA Damage Induced by Cerium Dioxide Nanoparticles: From Models to Molecular Mechanism Activated.- Mechanisms Underlying Neurotoxicity of Silver Nanoparticles.- Toxic and Beneficial Potential of Silver Nanoparticles: The Two Sides of the Same Coin.- Molecular and Cellular Toxicology of Nanomaterials with Related to Aquatic Organisms.- Cytotoxicity and Physiological Effects of Silver Nanoparticles on Marine Invertebrates.- A Drosophila Model to Decipher the Toxicity of Nanoparticles Taken Through Oral Routes.- Using of Quantum Dots in Biology and Medicine.