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Dahlem Mechanistic Relationships

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This text discusses the validity of the general thesis that mechanisms utilized in the development of the nervous system are reuti... Weiterlesen
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Beschreibung

This text discusses the validity of the general thesis that mechanisms utilized in the development of the nervous system are reutilized in the adult to mediate formation and maintenance of memory.

Klappentext

At the turn of the century, the pioneering neuroscientist Ramon y Cajal articulated the hypothesis that growth processes involved in the development of the central nervous system may persist into adulthood, where they might be retained to mediate the formation and maintenance of memory. Over the decades since Cajals seminal suggestion, extensive experimental attention has been directed at elucidating the cellular and molecular mechanisms underlying both neuronal development and learning and memory. Many exciting technical and conceptual advances have been made on each front. Thus, as we approach the end of this century, the field is now poised to assess the status of Cajals provocative hypothesis directly. This volume reflects a highly interdisciplinary dialog among experts in the fields of development and learning and memory, who came together not only to assess the validity of the general hypotheses that development and learning might share mechanistic features, but also to identify issues, preparations, and paradigms that would allow for a rigorous evaluation of ways to advance the hypothesis, on the one hand, and determine its fundamental limitations, on the other. Towards this end, the volume is organized into four levels of analysis: behavioral, systems, cellular, and molecular. At each level, neuroscientists from the general fields of development and learning engage in lively exchange of ideas which serve to highlight the similarities and differences of both the concepts and the experimental approaches used in their diverse fields. The result of this endeavor is a collection of seminal chapters and summary reports that provide a novel synthesis of important advances in twoexciting areas of modern neuroscience. Goal of this Dahlem Workshop: to evaluate the validity of the general thesis that mechanisms utilized in the development of the nervous system are reutilized in the adult to mediate formation and maintenance of memory.



Inhalt

What does behaviour tell us about the relationship between development and learning?; convergence of experimental and developmental approaches to animal learning and memory processes; development and learning in the birdsong system: are there shared mechanisms?; the development of language; to what extent are activity-dependent processes common to development and learning?; neurotrophins and visual system plasticity; correlational models of synaptic plasticity - development, learning, and cortical dynamics of mental representations; cerebellar motor learning, self-regulating plasticity, and implications for development; are the cellular mechanisms of synaptic development related to synaptic plasticity in the adult and to learning?; early steps in the development of cortical circuitry; synapse formation; the role of LTP and LTD in development and learning; do the molecular mechanisms that guide developmental connectivity also contribute to learning?; genes involved in cerebellar cell specification and differentiation; genetic analysis of learning and memory; genetic approaches to axon pathfinding.

Produktinformationen

Titel: Dahlem Mechanistic Relationships
Untertitel: Beyond Metaphor
Autor:
EAN: 9780471977025
ISBN: 0471977020
Format: Fester Einband
Genre: Medizin
Anzahl Seiten: 336
Gewicht: 664g
Größe: H229mm x B152mm x T24mm
Jahr: 1998

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