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Cardiovascular Genetics for Clinicians

  • Kartonierter Einband
  • 252 Seiten
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All physicians practicing medicine encounter patients suffering from cardiovascular disease. This book has been outlined in such a... Weiterlesen
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All physicians practicing medicine encounter patients suffering from cardiovascular disease. This book has been outlined in such a way that vascular surgeons, general internists, neurologists and cardiologists should be able to use it. The book covers the complete scope of cardiac diseases in addition to chapters on hypertension and atherosclerosis. In many patients there is a family history of cerebrovascular accidents, myocardial infarction or peripheral arterial disease. Also in patients reporting collaps, palpitations and arrhythmias the family is crucial and can provide clues to a genetic cause of the disease. This book is published to guide physicians in the process of determining whether a genetic component is likely to be present. Furthermore, information is provided what the possibilities and limitations of DNA diagnostic techniques are. Finally, the importance of newly identified categories of potential patients, i. e. gene carriers without symptoms or any inducible sign of disease, is highlighted. For some patients a genetic diagnosis is essential to determine appropriate therapy and for counseling? In some other diseases DNA diagnostic tools are available but the relevant for the patients may be less clear. In other families the search for a disease causing gene is ongoing and the possibilities to find genes and to unravel the pathophysiology of the disease is limited by the lack of patients. To give insight into the current state of genetic diagnostics, the authors have classified the cardiovascular diseases.


The first edition of Genetics for Clinicians is a handbook to help decision making in cardiovascular patients with a potentially inherited disease. First of all, the basics of molecular cardiology are introduced, followed by contributions of molecular geneticists and clinical geneticists, to show the disciplines involved in DNA diagnostics. Clinicians from around the globe discuss the relevance of genetics for their field of interest covering atherosclerosis, cardiomyopathy and arrhythmias. In addition, some rare but relevant connective tissue diseases are covered. In all the chapters the importance of DNA dianostics are categorized. This varies from the notion that a disease is inherited without information on genetics (Category F), to diseases where the exact location of the molecular defect determines the therapy (Category A). This simple classification is provided for the known inherited diseases to help the physician on how to advise and direct the patients. This is not a textbook for geneticists, but a practical guide for clinicians. In addition, the chapters give insight in etiology, pathophysiology and treatment of inherited cardiovascular diseases. Genetics for Clinicians can be read and used in daily practice without extensive knowledge of molecular cardiology.


List of Contributors. Preface. Introduction to Genetics. 1. Molecular Genetics in Cardiology; M.M.A.M. Mannens, H.J.M. Smeets. 2. Clinical Genetics; J.P. van Tintelen, et al. 3. Genetics of Congenital Heart Disease; P. Grossfeld. Atherosclerosis. 4. Genetics of Hypertension; A.A. Kroon, et al. 5. Lipoproteins and Atherosclerosis; J.C. Defesche, J.J.P. Kastelein. 6. Homocysteine, Genetic Determinants and Cardiovascular Risk; F.F. Willems, et al. 7. Genetic Markers of Hemostatic Factors; D. Girelli, et al. 8. The Pharmacogenetics of Atherosclerosis; J.W. Jukema, W.R.P. Agema. Connective Tissue Disorder. 9. Molecular Diagnosis of the Marfan Syndrome; P.N. Robinson. 10. Williams-Beuren Syndrome ans Supravalvular Aortic Stenosis; L. Pérez Jurado. Cardiomyopathy. 11. Mitochondrial Cardiomyopathy; R.J.E. Jongbloed, et al. 12. Hypertrophic Cardiomyopathy; L. Carrier, et al. 13. Dilated Cardiomyopathy; C. Marcelis, et al. Arrhythmias. 14. Idiopathic Ventricular Fibrillation; A.A. Wilde. 15. Diagnosis and Treatment of the Congenital Long QT Syndrome; X.H.T. Wehrens, et al. 16. Atrial Fibrillation; R. Brugada, R. Roberts. 17. Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy; A. Rampazzo, et al. Future of Genetics. 18. Genome Research and Future Healthcare; G.B. van Ommen. Index.


Titel: Cardiovascular Genetics for Clinicians
EAN: 9789401038881
ISBN: 9401038880
Format: Kartonierter Einband
Genre: Medizin
Anzahl Seiten: 252
Gewicht: 407g
Größe: H240mm x B160mm x T13mm
Jahr: 2012
Auflage: Softcover reprint of the original 1st ed. 2001



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