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Cardiac Mechano-Electric Coupling and Arrhythmias

  • Fester Einband
  • 512 Seiten
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Ranging from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm corr... Weiterlesen
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Ranging from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction, this new edition offers a thoroughly reviewed compendium of chapters, written by the top-experts in the world, on the mechanism and consequences of cardiac mechano-electrical coupling.

The original edition of this book was published over six years ago and was primarily intended for basic scientists. This edition is more than just a rewrite as it has been substantially updated with more than a 50% increase in chapters... The collected contributors represent the best basic scientists and clinical investigators in their field and as such the quality and clarity of the presentation is excellent throughout... There really is little else in this area to compare with and, as such, this book is excellent value for money.

Professor Peter Kohl, Chair in Cardiac Biophysics and r stems Biology at the National Heart and Lung Institute, Imperial College London, UK; Reader in Cardiac Physiology at the University of Oxford; Senior Fellow of the British Heart Foundation. His research crosses traditional boundaries between fields (engineering, biophysics, biology, computing) and levels (ion channel to whole organ) of investigation, focussing at cardiac structure-function relations with relevance for cardiac mechano-electric interactions. Professor Frederick Sachs, Distinguished Professor and Chair of Biophysics at State University of New York (SUNY), Buffalo NY, USA. As the original discoverer of mechano-sensitive ion channels in heart cells, he spearheaded their characterization, aided by his identification of a first selective inhibitor of these channels. More recently he developed the first fluorescent probes that sense mechanical stress in proteins, and he focuses now on their application to dystrophy and other diseases. Professor Michael R Franz, Director of Arrhythmia Research at the Veteran Medical Center and Adjunct Professor of Medicine and Pharmacology at Georgetown University Medical Center, Washington DC, USA. His development of a non-injuring technique to record monophasic action potentials has helped to study electrophysiology and arrhythmia mechanisms in patients world-wide. His own research has targeted cardiac electro-mechanics and stretch-induced arrhythmogenesis.

Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, right through to patient-based observations and insight emerging from clinical trials. The information provided carefully highlights both consensus insight and current shortcomings in our understanding of cardiac mechano-electric coupling. The book has been thoroughly revised and expanded since publication of the first edition in 2005, extensively updated to reflect recent developments in the field, and now offers a more balanced view of mechano-electrical interactions in the heart and develops a more clinical focus. Written with the practising cardiologist and junior doctor in mind, it offers interesting new insight for the established physician with an interest in cardiac arrhythmogenesis and heart rhythm management.


BASIC SCIENCE, SECTION I: SUB-CELLULAR MECHANISMS OF CARDIAC MECHANO-ELECTRIC COUPLING; 1. Evolutionary origins of stretch-activated ion channels; 2. SACs in the heart; 3. The mechano-gated K2P channel TREK-1 in the cardiovascular system; 4. Cell VolumeDSSensitive Ion Channels and Transporters in Cardiac Myocytes; 5. Non-sarcolemmal stretch-activated channels; 6. Pacemaker, potassium, calcium, sodium: stretch modulation of the voltage-gated channels; 7. Role of caveolae in stretch-sensing: implications for mechanoelectric coupling; 8. The membrane/cytoskeleton interface and stretch-activated channels; 9. Cardiomyocyte stretch sensing; 10. The response of cardiac muscle to stretch: Calcium and force; 11. Stretch effects on second messengers; 12. Functional implications of Myocyte Architecture; BASIC SCIENCE, SECTION II: CELLULAR MANIFESTATIONS OF CARDIAC MECHANO-ELECTRIC COUPLING; 13. Mechanical modulation of pacemaker electrophysiology; 14. Mechano-electric coupling in working cardiomyocytes: diastolic and systolic effects; 15. Mechano-sensitivity of pulmonary vein cells: implications for atrial arrhythmogenesis; 16. Heterogeneity of sarcomere length and function as a cause of arrhythmogenic calcium waves; 17. Cellular mechanisms of arrhythmogenic cardiac alternans; 18. Remodeling of gap junctions in ventricular myocardium: Effects of cell-to-cell adhesion, mediators of hypertrophy and mechanical forces; 19. The origin of fibroblasts, ECM and potential contributions to cardiac mechano-electric coupling; 20. Advantages and pitfalls of cell cultures as model systems to study cardiac mechanoelectric coupling; BASIC SCIENCE, SECTION III: MULTI-CELLULAR MANIFESTATIONS OF MECHANO-ELECTRIC COUPLING; 21. Activation sequence of cardiac muscle in simplified experimental models: Relevance for cardiac mechano electric coupling; 23. Acute stretch effects on atrial electro-physiology; 24. Stretch effects on potassium accumulation and alternans in pathological myocardium; 25. The effects of wall stretch on ventricular conduction and refractoriness in the whole heart; 26. Mechanical triggers of long-term ventricular electrical remodeling; 27. Mechanisms of mechanical pre- and postconditioning; TRANSLATIONAL SCIENCE, SECTION IV: INTEGRATED MODEL SYSTEMS TO STUDY SPECIFIC CASES OF CARDIAC MEC AND ARRHYTHMIAS; 28. Mechano-electric coupling in chronic atrial fibrillation; 29. Mechanically induced pulmonary vein ectopy - insight from animal models; 30. Regional variation in mechano-electric coupling: The right ventricle; 31. Mechanical induction of arrhythmia in the ex-situ heart: insight into Commotio Cordis; 32. Arrhythmias in murine models of the mechanically impaired heart; 33. Studying cardiac mechano-sensitivity in man; 34. Mathematical models of cardiac structure and function: mechanistic insights from models of heart failure; 35. Mathematical models of human atrial mechano-electrical coupling and arrhythmias; 36. Mathematical models of ventricular mechano-electric coupling and arrhythmia; CLINICAL RELEVANCE, SECTION V: PATHOPHYSIOLOGY OF CARDIAC MECHANO-ELECTRIC COUPLING: GENERAL ASPECTS; 37. Load dependence of ventricular repolarisation; 38. Is the U wave in the electrocardiogram a mechanoelectrical phenomenon?; 39. Mechanical modulation of cardiac function: Role of the pericardium; 40. Mechanically-induced electrical remodelling in human atrium; 41. Drug effects and atrial fibrillation: potential and limitations; 42. Stretch as a mechanism linking short- and long-term electrical remodeling in the ventricles; 43. Volume and pressure overload and ventricular arrhythmogenesis; 44. Stretch effects on fibrillation dynamics; CLINICAL RELEVANCE, SECTION VI: PATHOPHYSIOLOGY OF CARDIAC MECHANO-ELECTRIC COUPLING: SPECIFIC CASES; 45. Commotio cordis: Sudden death from blows to the chest wall; 46. Repolarization changes in the synchronously and dys-synchronously contracting failing heart; 47. Ventricular arrhythmias in heart failure: Link to hemodynamic load; 48. Mechanical heterogeneity and aftercontractions as trigger of torsades des poi


Titel: Cardiac Mechano-Electric Coupling and Arrhythmias
EAN: 9780199570164
ISBN: 978-0-19-957016-4
Format: Fester Einband
Herausgeber: Oxford University Press
Genre: Medizin
Anzahl Seiten: 512
Gewicht: 1760g
Größe: H282mm x B230mm x T30mm
Jahr: 2011



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