Cardiac Markers

Cardiac Markers is a comprehensive, up-to-date summary of clinical information on serum cardiac markers for coronary artery disease. This book reviews in detail the biochemistry, clinical significance, and analytical measurements for each marker, as well as the advantages and limitations of existing and proposed markers. Comprehensive descriptions of therapeutic approaches to manage patients are presented. Also included are up-to-date listings of primary references and commercial methodologies, the latest data on the pathophysiology of unstable angina, and a discussion of the new emergency-room chest pain centers. Anyone who needs to know how to examine, diagnose, treat, and manage patients with acute chest pain and heart attacks will find this book indispensable.

Zusammenfassung
"...addresses the need in a variety of disciplines for an understanding of the evolving role of cardiac markers, particularly in relation to the diagnosis and treatment of acute coronary syndromes. The book provides a concise and informative summary of a rapidly developing field and will be a useful addition to the book-shelves of clinical pathologists, emergency physicians, and cardiologists." -New England Journal of Medicine

"...a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical application...highly recommended for any individual interested in the state-of-the-art of appropriate laboratory assessment of the acute coronary syndrome patient." -Doody's Health Sciences Book Review Journal

"This comprehensive book not only offers physicians a complete guide to the use of cardiac markers in clinical practice, but also provides clinical laboratories with detailed information on the new markers which are now becoming standard." - Clinical Laboratory International

Inhalt
I Clinical Aspects.- 1 Introduction to Coronary Artery Disease (CAD) and Biochemical Markers.- 2 Pathophysiology of Acute Coronary Syndromes.- 3 Pathophysiology and Treatment of Acute Myocardial Ischemia and Infarction.- 4 Markers of Myocardial Injury in the Evaluation of the Emergency Department Patient with Chest Pain.- 5 Ultrastructure of the Striated Muscle Cell.- II Cytoplasmic Markers.- 6 Myoglobin and Carbonic Anhydrase III.- 7 Creatine Kinase, Isoenzymes, and Variants.- 8 CK-MB Activity Assays.- 9 CK-MB Measurements by Immunoassay.- 10 CK Isoforms.- 11 Lactate Dehydrogenase and Its Isoenzymes.- III Structural Markers.- 12 Biochemistry and Molecular Biology of Troponins I and T.- 13 Cardiac Troponin T as a Marker of Myocardial Injury.- 14 Cardiac Troponin I.- 15 Myosin Light and Heavy Chains.- IV Future Assay and Format.- 16 Point-of-Care Testing for Cardiac Markers.- 17 New Biochemical Markers for Heart Diseases.