Cancer Microenvironment and Therapeutic Implications

This book examines cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic.

In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don't always behave the same. Understanding and eradicating cancers will require an appreciation for cancer's ecology.

This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery.

The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.

A bird's-eye view of cancer biology A critical appraisal of cancer's context in addition to its substance Written by a team of physician-scientists merging experiences at the lab bench with the fight in the cancer clinic

Inhalt
Tumor Physiopathology and Microenvironment Genesis.- Inflammation and Carcinogenesis: A Change in the Metabolic Process.- Tumor Microenvironment: Aspects of Stromal-Parenchymal Interaction.- Significance of Tumor Microenvironment on the Genesis of: Interstitial Fluid, Angiogenesis, Haemostatic/Haemorheologic Abnormalities. Pathogenesis and Therapeutic Aspects.- Cancer, Stem Cells and the Neoplastic Niche.- Tumor Microenvironment, Therapeutic Perspectives and Strategies for Normalization.- Barriers to Drug Delivery in Cancer: Clinical Implications.- Hypoxia, Hyperthermia, Chemotherapy: Interactions and Opportunities.- Effects of Molecularly Targeting Hypoxia in Oncology.- Significance of the Tumour Microenvironment in Radiotherapy.- Effects of Tumor Microenvironment on Immunity and Consequent Clinical Considerations.- Effects of Tumor Microenvironment on Hyperthermia, Photodynamic and Nanotherapy.- Targeting Tumour Vascularization from Bench to Bedside: Suggestions for Combination with Hyperthermia.- New Indications for Established Drugs Able to Modify Tumour-Host Interactions.