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Cancer Metastasis: Biologic Basis and Therapeutics

  • Fester Einband
  • 642 Seiten
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This groundbreaking text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastat... Weiterlesen
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Zusammenfassung This groundbreaking text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field by integrating findings from multiple laboratories.


Dr. Danny R. Welch is current Leonard H. Robinson Professor of Pathology at University of Alabama at Birmingham. Dr. Welch actively holds numerous titles in various organizations, such as Co-Chair of the Program and Education Committees of American Association of Cancer Research, editor-in-chief of Clinical and Experimental Metastasis, and Chair of the Cancer Genetics Study Section at the National Institute of Health. Dr. Welch has published 6 books and holds 5 patents. Dr. David Lyden is the Stavros S. Niarchos Associate Professor in Pediatrics and Cell and Developmental Biology at the Children's Cancer and Blood Foundation Laboratories at Weill Cornell Medical College. He is a Neuro-oncologist at Memorial Sloan-Kettering Cancer Center. Also, Dr. Lyden is an Investigator of the Champalimaud Foundation, the first research, prevention and treatment center for metastatic disease. In 2007, Dr. Lyden received the Presidential Medical Distinction Award from President Cavaco Silva of Portugal. Dr. Bethan Psaila is a Research Fellow at Imperial College of Medicine in London and Weill Cornell Medical College of New York. Dr. Psaila is the recipient of a Fulbright Scholarship in Cancer Research and a Kay Kendall Leukaemia Fund Travelling Fellowship.


This text, written by internationally renowned authors, describes the processes underlying cancer metastasis and the clinical treatment of metastatic disease.


Overview Josh Fidler; 1. Introduction to basic research Harold Moses; Part I. Basic Research: 2. Animal models of metastasis Janet Price; 3. Non-traditional models of metastasis including drosophilia Elisa Woodhouse; 4. Computational models of metastasis Wayne Kendal; 5. Metastatic inefficiency and tumor dormancy Ann Chambers; 6. The role of the epithelial-mesenchymal transition (EMT) and MET in metastasis Erik Thompson, Donald Newgreen, and Lilian Soon; 7. Proteolytic pathways in metastasis Johanna Joyce; 8. The role of matrix metalloproteinases in tumor invasion and metastasis Barbara Fingleton; 9. The role of the urokinase system in invasion and metastasis Julio Aguirre-Ghiso; 10. Apoptotic and anoikis mechanisms controlling steps of the metastatic cascade Kounosuke Watabe; 11. Intra-vital video microscopy to visualize invasion and metastasis Erik Sahai; 12. The influence of inflammation and chemokines in metastasis Michael Karin; 13. How aging and cellular senescence influences metastasis Futoshi Okada and Hiroshi Kobayashi; 14. Hematopological vs. lymphatic metastasis: a comparison of tumor cell interactions with vascular vs. lymphatic endothelium Marc Achen, Steven Stacker, and Tara Karezis; 15. The role of microparticles in metastasis Hector Peinado and Bethan Psaila; 16. Endothelial-specific markers that determine organ-specificity of metastasis Renata Pasqualini; 17. Mechanisms of organ selectivity Yibin Kang; 18. Growth regulatory pathways that determine organ selectivity of metastasis Suzanne Eccles; 19. The pre-metastatic niche Mariannna Papaspyridonos and Rosandra Kaplan; 20. Metastasis-promoting genes Paul Fisher; 21. Metastasis-suppressor genes Patricia Steeg and Carrie Rinker-Schaeffer; 22. Epigenetic regulation of metastasis Manel Esteller; 23. Host determinants of metastatic potential Nigel Crawford; Part II. Clinical Research: 24. Introduction to clinical section Nancy E. Davidson; 25. Sarcomas Lee Helman and Chand Khanna; 26. Neuroblastoma Nai Kong Cheung; 27. Retinoblastoma David Abramson; 28. Primary brain tumors and cerebral metastases Mitchel Berger; 29. Head and neck Ketayun Dinshaw; 30. Melanomas John Kirkwood; 31. Gastric Yasuhide Yamada; 32. Pancreas Jose Eduardo Monteiro Cunha; 33. Liver (primary and hepatic metastases) Zhao-you Tang; 34. Colon Andrea Wang-Gillam; 35. Lung Rafael Rosell-Costa; 36. Thyroid Michael Tuttle; 37. Kidney cancer metastasis Jean Jacques; 38. Bladder Dan Theodorescu; 39. Myeloma/ Lymphoma G. David Roodman; 40. Breast metastasis Heather L. McArthur, Clifford A. Hudis, and Patrick Morris; 41. OBGYN S. Diane Yamada; 42. Prostate cancer metastasis Kenneth Pienta; 43. Testicular and germ cell Robert Hromas; 44. Proteomics and molecular markers Lance Liotta; 45. Bone marrow / MRD Klaus Pantel; 46. Sentinel lymph nodes Jeffrey Gershenwald; 47. Molecular imaging and metastasis Lily Wu; 48. Complications of bone metastases including nerve pain Robert E. Coleman; 49. Coagulation Simon Karpatkin and David Green; 50. Nanoparticles P. Charles Lin; 51. Metronomics Robert Kerbel; 52. Therapeutics Paul Elvin; 53. Immunotherapy Pier-Luigi Lollini, Patrizia Nanni and Carla DeGiovanni; 54. Radiotherapy Hak Choy; 55. Regulatory issues surrounding clinical trials of anti-metastatic therapies George W. Sledge, Jr.


Titel: Cancer Metastasis: Biologic Basis and Therapeutics
Untertitel: Biologic Basis and Therapeutics
EAN: 9780521887212
ISBN: 978-0-521-88721-2
Format: Fester Einband
Herausgeber: Cambridge Univ Pr
Genre: Medizin
Anzahl Seiten: 642
Gewicht: 2064g
Größe: H279mm x B216mm x T33mm
Jahr: 2011



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