Cancer in Transplantation: Prevention and Treatment

Malignancies are frequent complications in organ transplantation, mainly as the result of infection with certain viruses and of long-term immunosuppression. The epidemiology confirms that the increased incidence concerns certain cancers, especially HIV-related skin cancers and EBV-related lymphoproliferative malignancies.
This book covers all currently available information on this important topic of the relationships between transplantation and malignancies: preexisting cancers, posttransplant cancers, their etiology and pathophysiology, their prevention and treatment. A significant part of the volume is devoted to prophylaxis, early detection and modern forms of therapy in posttransplant lymphomas. As a conclusion of all these new data, the theory of immunosurveillance deserves to be significantly modified.

Zusammenfassung
` ...significant amount of new data. The text ... provides interesting data on the epidemiology of malignancies following transplantation, and also on their pathogenesis, management, and potential treatment. In view of the increasing number of patients undergoing transplantation this book is to be welcomed.'
Nephrology Dialysis Transplantation, 13 (1998)

Inhalt
Part One: Epidemiology. 1. Epidemiology of Cancer in Transplant Patients; I. Penn. 2. Multicenter Analysis of Posttransplant Malignancies; G. Opelz. 3. German Multicenter Analysis of Malignancies Following Renal Replacement Therapy in Children; A.M. Wingen. 4. Malignancies Transmitted with the Transplant; N. Lefrançois. Part Two: Malignancies Preexisting to Transplantation. 5. Outcome of Preexisting Urological Tumours in Dialysis and in Renal Transplant Recipients; G. Karam. 6. Screening for Breast and Gynaecologic Carcinomas in Transplant Patients; P. Mathevet. 7. Results of Renal Transplantation for Wilm's Tumour; M.F. Gagnadoux. 8. Prevention of recurrence after Liver Transplantation for Hepatocellular Carcinoma; H. Bismuth. Part Three: De Novo Malignancies After Transplantation. 9. Skin Cancers in Organ Transplant Recipients; S. Evurard. 10. Kaposi's Sarcoma in Organ Transplantation; J.L. Touraine. 11. Human T-Cell Leukemia Virus Type I (HTLV_I) and Transplantation; A. Bazarbachi. 12. Hepatitis B Virus and Primary Liver Cancer in Hepatitis B Surface Antigen Positive and Negative Patients; P. Paterlini. 13. Malignancies in Patients with Pancreas and Kidney Transplants; D. Cantarovich. Part Four: Immunosuppression and Cancer. 14. Cancer Risk Factors in Transplantation; E. Alamartine. 15. Risk of Cancer in Transplant Patients Treated with Recombinant Growth Hormone; P. Cochat. 16. Malignancies in Transplant Patients under Cyclosporine Treatment for More than 10 years;U. Frei. 17. Risk of Malignancies in Patients Treated with Sandimmun for Autoimmune Disease; V. Lamarque. 18. De Novo Malignancies Following Renal Transplantation; N. Yoshimura. Part Five: Epstein-Barr Virus Related Malignancies. 19. Virus Induced Cancer: The Lesson ofEpstein-Barr Virus; M.G. Masucci. 20. Nonlymphoid Epstein-Barr Virus Induced Neoplasms after Organ Transplantation; P.S. Dickman. 21. The Epstein- Barr Virus Latency and Reactivation; A. Sergeant. 22. Earl Detection of EBV Infection and Meaning in Transplant Patients; E.B. Drouet. 23. Lymphomas in the scid/hu Mice: Effect of EBV on Human B-Cells in Vivo; J.L. Garnier. Part Six: Lymphoproliferative Syndromes after Transplantation. 24. Types of Lymphomas in Transplant and Other Immunosuppressed patients; M. Raphael. 25. Cytokines from Lymphoid Organs of HIV- Infected Patients: Production and Role of Cytokine sin Lymphoproliferations of Immune Deficiency; D. Emilie. 26. Interleukin 10 and non Hodgkin's Lymphomas; N. Voorzanger. 27. Serum Monoclonal Immunoglobulins in Renal Transplant Recipients: A Study Using High Resolution Electrophoresis and Western Blotting; G. Touchard. 28. Increased Risk of Lymphoproliferative Disorders Following the Use of Okts: Association with Cumulative Dose; L.J. Swinnen. 29. Clinical Characteristics of Lymphoproliferations after Renal Transplantation. Nantes Experience; J. Dantal. 30. Therapeutic Issues in Lymphoproliferative Disorder: Treatment and Outcome of 28 Cases Observed in a Single Center; V. Leblond. 31. Ant