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Cancer Epigenetics

  • Kartonierter Einband
  • 508 Seiten
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This Methods in Molecular Biology(TM) volume reviews epigenetic changes in different tumor types and outlines currently available ... Weiterlesen
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This Methods in Molecular Biology(TM) volume reviews epigenetic changes in different tumor types and outlines currently available technologies for detecting epigenetic changes. Includes detailed descriptions and implementation advice for optimal lab results.

The epigenetic regulation plays an important role in normal development and maintenance of tissue specific genes expression in humans and the disturbance of these patterns lead to changes involved in tumor formation. More recently, epigenetic changes have been observed in early stages of tumor development and together with the genetic alterations have been defined as abnormalities, necessary for cancer initiation and progression. In, Cancer Epigenetics: Methods and Protocols , expert researchers reviewed these epigenetics changes in different tumor types and described several technologies that are currently available to detect epigenetic changes. These technologies have lead to a better understanding of the processes in normal and cancerous cells. Written in the highly successful Methods in Molecular Biology (TM) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Cancer Epigenetics: Methods and Protocols aids scientists in continuing to study epigenetic alterations used in clinical practice as biomarkers of early cancerous lesions or markers of progression and prognosis.

From the reviews: "This book provides a clear description of the epigenetic changes in cancer that are important in early detection, progression, and prognosis, as well as the design of therapeutic tools necessary to combat cancer. ... This is an excellent resource for scientists and oncologists interested in learning about currently available technologies to detect epigenetic changes that serve as biomarkers in detection of early cancerous lesions as well as markers of cancer progression and prognosis." (Omer Iqbal, Doody's Book Reviews, August, 2012)


Part I: Early Epigenetic Events in Cancer 1. Epigenetic Markers of Early Tumor DevelopmentRamona G. Dumitrescu2. Epigenetics of Solid Cancer Stem CellsAlok Mishra and Mukesh Verma Part II: Cancer Specific Type Epigenetic Changes3. DNA Methylation and Histone Modifications in Breast CancerRamona G. Dumitrescu 4. DNA Methylation Changes in Prostate CancerWolfgang Goering, Michael Kloth, Wolfgang A. Schulz5. DNA Methylation in Promoter Region as Biomarkers in Prostate CancerMihi Yang and Jong Y. Park 6. Epigenetics of Bladder CancerWun-Jae Kim and Yong-June Kim 7. Epigenetics in Myeloid MalignanciesStefan Deneberg 8. The Epigenetics of Brain TumorsAdrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott and Michael D. Taylor9. DNA Methylation Changes in Cervical CancersQiang Lu, Dehua Ma, Shuping Zhao10. Epigenetics of Colon CancerSharad Khare and Mukesh Verma11. Promoter Methylation in Head and Neck TumorigenesisJosena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, Maria J. Worsham 12. Epigenome and DNA Methylation in Oral Squamous Cell CarcinomaMario Pérez-Sayáns García and Abel García-García13. Clinical Implications of Epigenetic Alterations in Human Thoracic Malignancies: Epigenetic Alterations in Lung CancerKeiko Shinjo and Yutaka Kondo 14. The Role of microRNAs in the Management of Liver CancerKrishna K Banaudha and Mukesh Verma15. Epigenetics in Ovarian CancerL.M.S. Seeber, P.J. van Diest Part III: Methods and Technologies used for Epigenetic Changes Detection 16. DNA Methylation in Pancreatic Cancer: Protocols for the Isolation of DNA and Bisulfite ModificationKatja Biewusch, Marie Heyne, Robert Grützmann, Christian Pilarsky17.Detection and Analysis of DNA Methylation by PyrosequencingHilary A. A. Colyer, Richard N. Armstrong, Dr. Daniel J. Sharpe and Ken I. Mills 18. Screening for miRNA Experssion Changes using Quantitative PCR (Q-PCR)Richard N. Armstrong, Hilary A. A. Colyer, Ken. I. Mills19. Genome-wide Methylation AnalysisAlexander Unterberger, Adrian M. Dubuc and Michael D. Taylor 20. Microarray for Epigenetic Changes: Gene Expression ArraysHilary A. A. Colyer, Richard N. Armstrong and Ken I. Mills21. Detecting DNA Methylation using the Methylated CpG Island Amplification and Microarray TechniqueHiliary A. A. Colyer, Margaret Dellett and Ken I. MillsPart IV. Factors that Influence the Epigenetic Changes in Cancer22. Nutrigenomics-Implications for Breast and Colon Cancer PreventionGabriela Riscuta and Ramona G. Dumitrescu23. Dietary and Lifestyle Factors of DNA MethylationUnhee Lim and Min-Ae Song 24. Diet, Epigenetics and Cancer Joseph L. Su 25. Role of Epigenetics in Cancer Health DisparitiesSulma I. Mohammed, Sanya Springfield, and Rina Das26. Multifactorial Etiology of Gastric CancerRosa A. Sierra, Jovanny ZabaletaPart V. Epigenetic Epidemiology 27. Epigenetic Epidemiology for Cancer Risk: Harnessing Germline Epigenetic VariationKevin Brennan and James M. Flanagan 28. Epigenetic Biomarkers in Cancer EpidemiologyMukesh Verma


Titel: Cancer Epigenetics
Untertitel: Methods and Protocols
EAN: 9781493962044
ISBN: 1493962043
Format: Kartonierter Einband
Genre: Medizin
Anzahl Seiten: 508
Gewicht: 943g
Größe: H254mm x B178mm x T27mm
Jahr: 2016
Auflage: Softcover reprint of the original 1st ed. 2012.



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