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Cancer Epigenetics

  • Kartonierter Einband
  • 492 Seiten
This Methods in Molecular Biology(TM) volume reviews epigenetic changes in different tumor types and outlines currently available ... Weiterlesen
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Beschreibung

This Methods in Molecular Biology(TM) volume reviews epigenetic changes in different tumor types and outlines currently available technologies for detecting epigenetic changes. Includes detailed descriptions and implementation advice for optimal lab results.

The epigenetic regulation plays an important role in normal development and maintenance of tissue specific genes expression in humans and the disturbance of these patterns lead to changes involved in tumor formation. More recently, epigenetic changes have been observed in early stages of tumor development and together with the genetic alterations have been defined as abnormalities, necessary for cancer initiation and progression. In, Cancer Epigenetics: Methods and Protocols , expert researchers reviewed these epigenetics changes in different tumor types and described several technologies that are currently available to detect epigenetic changes. These technologies have lead to a better understanding of the processes in normal and cancerous cells. Written in the highly successful Methods in Molecular Biology (TM) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Cancer Epigenetics: Methods and Protocols aids scientists in continuing to study epigenetic alterations used in clinical practice as biomarkers of early cancerous lesions or markers of progression and prognosis.

Zusammenfassung
From the reviews: "This book provides a clear description of the epigenetic changes in cancer that are important in early detection, progression, and prognosis, as well as the design of therapeutic tools necessary to combat cancer. ... This is an excellent resource for scientists and oncologists interested in learning about currently available technologies to detect epigenetic changes that serve as biomarkers in detection of early cancerous lesions as well as markers of cancer progression and prognosis." (Omer Iqbal, Doody's Book Reviews, August, 2012)

Inhalt
Part I: Early Epigenetic Events in Cancer 1. Epigenetic Markers of Early Tumor Development Ramona G. Dumitrescu 2. Epigenetics of Solid Cancer Stem Cells Alok Mishra and Mukesh Verma Part II: Cancer Specific Type Epigenetic Changes 3. DNA Methylation and Histone Modifications in Breast Cancer Ramona G. Dumitrescu 4. DNA Methylation Changes in Prostate Cancer Wolfgang Goering, Michael Kloth, Wolfgang A. Schulz 5. DNA Methylation in Promoter Region as Biomarkers in Prostate Cancer Mihi Yang and Jong Y. Park 6. Epigenetics of Bladder Cancer Wun-Jae Kim and Yong-June Kim 7. Epigenetics in Myeloid Malignancies Stefan Deneberg 8. The Epigenetics of Brain Tumors Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott and Michael D. Taylor 9. DNA Methylation Changes in Cervical Cancers Qiang Lu, Dehua Ma, Shuping Zhao 10. Epigenetics of Colon Cancer Sharad Khare and Mukesh Verma 11. Promoter Methylation in Head and Neck Tumorigenesis Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, Maria J. Worsham 12. Epigenome and DNA Methylation in Oral Squamous Cell Carcinoma Mario Pérez-Sayáns García and Abel García-García 13. Clinical Implications of Epigenetic Alterations in Human Thoracic Malignancies: Epigenetic Alterations in Lung Cancer Keiko Shinjo and Yutaka Kondo 14. The Role of microRNAs in the Management of Liver Cancer Krishna K Banaudha and Mukesh Verma 15. Epigenetics in Ovarian Cancer L.M.S. Seeber, P.J. van Diest Part III: Methods and Technologies used for Epigenetic Changes Detection 16. DNA Methylation in Pancreatic Cancer: Protocols for the Isolation of DNA and Bisulfite Modification Katja Biewusch, Marie Heyne, Robert Grützmann, Christian Pilarsky 17.Detection and Analysis of DNA Methylation by Pyrosequencing Hilary A. A. Colyer, Richard N. Armstrong, Dr. Daniel J. Sharpe and Ken I. Mills 18. Screening for miRNA Experssion Changes using Quantitative PCR (Q-PCR) Richard N. Armstrong, Hilary A. A. Colyer, Ken. I. Mills 19. Genome-wide Methylation Analysis Alexander Unterberger, Adrian M. Dubuc and Michael D. Taylor 20. Microarray for Epigenetic Changes: Gene Expression Arrays Hilary A. A. Colyer, Richard N. Armstrong and Ken I. Mills 21. Detecting DNA Methylation using the Methylated CpG Island Amplification and Microarray Technique Hiliary A. A. Colyer, Margaret Dellett and Ken I. Mills Part IV. Factors that Influence the Epigenetic Changes in Cancer 22. Nutrigenomics-Implications for Breast and Colon Cancer Prevention Gabriela Riscuta and Ramona G. Dumitrescu 23. Dietary and Lifestyle Factors of DNA Methylation Unhee Lim and Min-Ae Song 24. Diet, Epigenetics and Cancer Joseph L. Su 25. Role of Epigenetics in Cancer Health Disparities Sulma I. Mohammed, Sanya Springfield, and Rina Das 26. Multifactorial Etiology of Gastric Cancer Rosa A. Sierra, Jovanny Zabaleta Part V. Epigenetic Epidemiology 27. Epigenetic Epidemiology for Cancer Risk: Harnessing Germline Epigenetic Variation Kevin Brennan and James M. Flanagan 28. Epigenetic Biomarkers in Cancer Epidemiology Mukesh Verma

Produktinformationen

Titel: Cancer Epigenetics
Untertitel: Methods and Protocols
Editor:
EAN: 9781493962044
ISBN: 978-1-4939-6204-4
Format: Kartonierter Einband
Genre: Medizin
Anzahl Seiten: 492
Gewicht: 957g
Größe: H254mm x B254mm x T178mm
Jahr: 2016
Auflage: Softcover reprint of the original 1st ed. 2012
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